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Until recently, it was thought that myocardium was not able to repair itself, but studies have now shown that resident cardiac stem cells have regenerative capacity, and stem cell therapy may be a novel approach for cardiac muscle repair and regeneration. Stem cell\u2010derived paracrine factors have been shown to regulate ventricular remodeling, inflammation, apoptosis, cardiomyocytes regeneration, and neovascularization in regions of infarcted cardiac tissue. In this review, we summarize the evidence from cellular, animal, and clinical studies supporting the potential clinical significance of stem cell therapy as a novel therapeutic approach for the treatment of MI.<\/jats:p>","DOI":"10.1002\/jcp.28381","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T09:06:26Z","timestamp":1551258386000},"page":"16904-16912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Stem cell therapy: A novel approach for myocardial infarction"],"prefix":"10.1002","volume":"234","author":[{"given":"Seyed Mostafa","family":"Parizadeh","sequence":"first","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Jafarzadeh\u2010Esfehani","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of 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