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Wear\u2010particle\u2010induced osteoclastogenesis has been shown to be the primary cause of periprosthetic osteolysis that eventually leads to aseptic prosthesis loosening. Therefore, inhibiting osteoclastogenesis is a promising strategy to control periprosthetic osteolysis. The possible mechanism of action of rhoifolin on osteoclastogenesis and titanium particle\u2010induced calvarial osteolysis was examined in this study. The in vitro study showed that rhoifolin could strongly suppress the receptor activators of nuclear factor\u2010\u03baB (NF\u2010\u03baB) ligand\u2010stimulated osteoclastogenesis, hydroxyapatite resorption, F\u2010actin formation, and the gene expression of osteoclast\u2010related genes. Western blot analysis illustrated that rhoifolin could attenuate the NF\u2010\u03baB and mitogen\u2010activated protein kinase pathways, and the expression of transcriptional factors nuclear factor of activated T cells 1 (NFATc1) and c\u2010Fos. Further studies indicated that rhoifolin inhibited p65 translocation to the nucleus and the activity of NFATc1 and NF\u2010\u03baB rhoifolin could decrease the number of tartrate\u2010resistant acid phosphate\u2010positive osteoclasts and titanium particle\u2010induced C57 mouse calvarial bone loss in vivo. In conclusion, our results suggest that rhoifolin can ameliorate the osteoclasts\u2010stimulated osteolysis, and may be a potential agent for the treatment of prosthesis loosening.<\/jats:p>","DOI":"10.1002\/jcp.28384","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:31:00Z","timestamp":1552264260000},"page":"17600-17611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Rhoifolin ameliorates titanium particle\u2010stimulated osteolysis and attenuates osteoclastogenesis via RANKL\u2010induced NF\u2010\u03baB and MAPK pathways"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-0883","authenticated-orcid":false,"given":"Shijie","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Trauma Orthopedic and Hand Surgery The First Affliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key 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