{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:05:09Z","timestamp":1784293509883,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our work aims to elucidate the effect how microRNA\u2010148b (miR\u2010148b) participated in myocardial ischemia\/reperfusion (I\/R) injury via regulation of Wnt\/\u03b2\u2010catenin signaling pathway. The in vivo myocardial I\/R models of SD rats and in vitro hypoxia\/reoxygenation (H\/R) models of H9C2 cells were established. The heart function and infarction area of rats and lactic dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), and superoxide dismutase (SOD) levels were evaluated. Myocardial cell viability was measured using positron emission tomography combined with computer tomography and (3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide) assay, and the apoptosis was assessed by terminal deoxynucleotidyl transferase\u2010mediated nick\u2010end labeling method and flow cytometry; quantitative reverse\u2010transcription polymerase chain reaction and western blot were used to detect the related molecules expressions. The myocardial infarction area of rats was significantly increased with reductions in LVSP, +\u2009dp\/dtmax, \u2212\u2009dp\/dtmax, LVFS%, LVEF% and standardized uptake value and elevation in left ventricular developed pressure after ischemia\/reperfusion (I\/R), and the LDH, CK, and MDA levels were enhanced with the decreased SOD. The apoptotic rates were higher in I\/R rats and H\/R H9C2 cells with upregulated miR\u2010148b and cleaved caspase\u20103, but decreased Bcl\u20102\/Bax ratio; and meanwhile, the Wnt\/\u03b2\u2010catenin pathway was inhibited. Additionally, the H\/R\u2010induced H9C2 cells also exhibited decreased cell viability. MiR\u2010148b overexpression further aggravated I\/R injury of rats, whereas inhibition of miR\u2010148b reduced I\/R and H\/R injury through activation of Wnt\/\u03b2\u2010catenin pathway. In addition, Wnt\u20101 small interfering RNA exposure abolished the effect of miR\u2010148b inhibitor on H\/R injury of H9C2 cells. Inhibition of miR\u2010148b improved the antioxidative ability and myocardial cell survival to suppress its apoptosis by activating Wnt\/\u03b2\u2010catenin signaling pathway, thus ameliorating the myocardial I\/R injury.<\/jats:p>","DOI":"10.1002\/jcp.28401","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T23:37:56Z","timestamp":1551397076000},"page":"17757-17766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Inhibition of miR\u2010148b ameliorates myocardial ischemia\/reperfusion injury via regulation of Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-1810","authenticated-orcid":false,"given":"Mei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The Third People's Hospital of Jinan City Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Yan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Third People's Hospital of Jinan City Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Shandong Provincial Western Hospital Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"issue":"2","key":"e_1_2_8_1_2_1","first-page":"101","article-title":"Effect of HEMADO on level of CK\u2010MB and LDH enzymes after ischemia\/reperfusion injury in isolated rat heart","volume":"3","author":"Amani M.","year":"2013","journal-title":"Bioimpacts"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-005-0765-6"},{"issue":"4","key":"e_1_2_8_1_4_1","first-page":"199","article-title":"Revised guide for the Care and Use of Laboratory Animals Available","volume":"39","author":"Bayne K.","year":"1996","journal-title":"Physiologist"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i18.2936"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.01.007"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-43"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602700200"},{"issue":"7","key":"e_1_2_8_1_9_1","first-page":"10420","article-title":"Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia\u2010reperfusion injury: Role of Nrf2\/ARE pathway","volume":"8","author":"Cheng L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536012117704767"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1661-0_1"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000507"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488049"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2008.195933"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182764fe8"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1636"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.11.006"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1024"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.06.017"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.163375"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.2971"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.016"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00935.2003"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1427"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules161210002"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814145"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03319"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006172107"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(99)00158-5"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485884"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25208"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2360"},{"key":"e_1_2_8_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-010-0776-9"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00329"},{"key":"e_1_2_8_1_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070956"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00413.2008"},{"key":"e_1_2_8_1_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00685.2016"},{"key":"e_1_2_8_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.05.007"},{"key":"e_1_2_8_1_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq053"},{"key":"e_1_2_8_1_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193845"},{"key":"e_1_2_8_1_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0418-4"},{"key":"e_1_2_8_1_42_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-147"},{"key":"e_1_2_8_1_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/481405"},{"key":"e_1_2_8_1_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38480"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:46:42Z","timestamp":1784292402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,28]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jcp.28401"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28401","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,28]]},"assertion":[{"value":"2018-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}