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This family includes four subtypes (JP1\u20134), which are differentially detected in excitable cells. Previous work demonstrated the knockout of JPs that seriously damage physiological functions in skeletal muscle, cardiac, and neurons. Here, we summarize latest papers on the essential function of JPs in some Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010related diseases and neurological diseases, such as primary muscle disease, cardiomyopathies, Type 2 diabetes, gastrointestinal cancer, Huntington\u2019s disease\u2010like 2, and Charcot\u2010Marie\u2010Tooth disease. 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