{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:05:59Z","timestamp":1784293559967,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["15622\u20105"],"award-info":[{"award-number":["15622\u20105"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thyroid hormones have a role in the regulation of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) biosynthesis. In this study, we determined the effects of hyperthyroidism on H\n                    <jats:sub>2<\/jats:sub>\n                    S levels in various tissues and messenger RNA (mRNA) expression of cystathionine\u2010\u03b2\u2010synthase (CBS), cystathionine\u2010\u03b3\u2010lyase (CSE), and 3\u2010mercaptopyruvate sulfurtransferase (3\u2010MST) in the liver and muscles of the rat. Sixteen male Wistar rats were divided into the hyperthyroid and the control groups. Hyperthyroidism was induced by adding\n                    <jats:sc>l<\/jats:sc>\n                    \u2010thyroxine (12\u2009mg\/L) to drinking water for a period of 21 days. H\n                    <jats:sub>2<\/jats:sub>\n                    S concentrations in serum, liver, aorta, heart, and soleus muscles, as well as mRNA expressions of CBS, CSE, and 3\u2010MST in these tissues were measured at Day 21. Hyperthyroid rats had lower H\n                    <jats:sub>2<\/jats:sub>\n                    S levels in the serum compared with controls (14.7\u2009\u00b1\u20091.4 vs. 25.7\u2009\u00b1\u20091.6\u2009\u00b5mol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compared with controls, hyperthyroid rats had lower levels of H\n                    <jats:sub>2<\/jats:sub>\n                    S in the aorta (89%), heart (80%), and soleus (103%) muscles, but higher levels in the liver (35%). Hyperthyroidism decreased the ratio of CBS\/CSE mRNA expression in the liver and the CSE\/CBS mRNA expression in the muscles by decreasing CBS levels in liver (34% cf. controls) and CSE levels in the aorta, heart, and soleus muscles (respectively, 51%, 7%, and 52% cf.). In addition, hyperthyroidism decreased the mRNA expression of 3\u2010MST in the liver (51%) and aorta (33%), and increased it in the heart (300%) and soleus muscle (182%). In conclusion, hyperthyroidism increased H\n                    <jats:sub>2<\/jats:sub>\n                    S levels in the liver and decreased it in muscles; these effects are at least in part due to increases and decreases in expression of CSE in the liver and muscles, respectively. These data indicate an association between thyroid hormone status and gene expression of the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing enzymes in the rat.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28426","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:45:49Z","timestamp":1551487549000},"page":"17937-17945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered gene expression of hydrogen sulfide\u2010producing enzymes in the liver and muscles tissues of hyperthyroid rats"],"prefix":"10.1002","volume":"234","author":[{"given":"Sajad","family":"Jeddi","sequence":"first","affiliation":[{"name":"Endocrine Physiology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Gholami","sequence":"additional","affiliation":[{"name":"Endocrine Physiology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"Gheibi","sequence":"additional","affiliation":[{"name":"Endocrine Physiology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khosrow","family":"Kashfi","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education City University of New York School of Medicine New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-2151","authenticated-orcid":false,"given":"Asghar","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Endocrine Physiology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"issue":"2","key":"e_1_2_8_1_2_1","first-page":"155","article-title":"The effect of thyroid activity on adult rat spermatogenesis","volume":"8","author":"Ai J.","year":"2007","journal-title":"Iranian Journal of Veterinary Research"},{"issue":"7","key":"e_1_2_8_1_3_1","first-page":"703","article-title":"The long\u2010term regulation of food intake and body weight depends on the availability of thyroid hormones in the brain","volume":"33","author":"Alva\u2010Sanchez 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