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We hypothesized that reduced tumor burden by selective treatment of tumor with immunomodulators may exert beneficial effects on muscle wasting and function in mice. Body and muscle weight, grip strength, physical activity, muscle morphometry, apoptotic nuclei, troponin\u2010I systemic levels, interleukin\u20106, proteolytic markers, and tyrosine release, and apoptosis markers were determined in diaphragm and gastrocnemius muscles of lung cancer (LP07 adenocarcinoma cells) mice (BALB\/c) treated with monoclonal antibodies (mAbs), against immune check\u2010points and pathways (CD\u2010137, cytotoxic T\u2010lymphocyte associated protein\u20104, programed cell death\u20101, and CD\u201019;\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200910\/group). Nontreated lung cancer cachectic mice were the controls. T and B cell numbers and macrophages were counted in tumors of both mouse groups. Compared to nontreated cachectic mice, in the mAbs\u2010treated animals, T cells increased, no differences in B cells or macrophages, the variables final body weight, body weight and grip strength gains significantly improved. In diaphragm and gastrocnemius of mAbs\u2010treated cachectic mice, number of apoptotic nuclei, tyrosine release, proteolysis, and apoptosis markers significantly decreased compared to nontreated cachectic mice. Systemic levels of troponin\u2010I significantly decreased in treated cachectic mice compared to nontreated animals. We conclude that reduced tumor burden as a result of selective treatment of the lung cancer cells with immunomodulators elicits per se beneficial effects on muscle mass loss through attenuation of several biological mechanisms that lead to increased protein breakdown and apoptosis, which translated into significant improvements in limb muscle strength but not in physical activity parameters.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28437","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T06:49:48Z","timestamp":1552114188000},"page":"18041-18052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reduced lung cancer burden by selective immunomodulators elicits improvements in muscle proteolysis and strength in cachectic mice"],"prefix":"10.1002","volume":"234","author":[{"given":"Anna","family":"Salazar\u2010Degracia","sequence":"first","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Granado\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efna","family":"Mill\u00e1n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Pons\u2010Carreto","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-3443","authenticated-orcid":false,"given":"Esther","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Pulmonology Department\u2010Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS) MIM\u2010Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,9]]},"reference":[{"issue":"1","key":"e_1_2_10_1_2_1","first-page":"2","article-title":"Recommendations of the Spanish Society of Pneumology and Thoracic Surgery on the diagnosis and treatment of non\u2010small\u2010cell lung cancer","volume":"52","author":"\u00c1lvarez F. 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