{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:13:12Z","timestamp":1789413192954,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pterygium as a complex disease shares common features with other malignant cells in its onset recurrence and especially epithelial\u2013mesenchymal transition (EMT) transition. Although using different approaches including conjunctival autografts, amniotic membrane, radiotherapy, mitomycin C (MMC) has shown promising insights in the inhibition of pterygium recurrence, it needs to be investigated in more details in molecular pathways to present adjuvant target therapy. In this study, we aimed to evaluate the expression of and then illustrate the role of signaling pathways on EMT in pterygium. Using real\u2010time polymerase chain reaction, the twist\u2010related protein 1\n                    <jats:italic>(TWIST1<\/jats:italic>\n                    ) expression was compared in primary pterygium and normal conjunctiva. This study assessed the mRNA expression, as well as the association between the clinicopathological indices and the gene expression level. The expression level of\n                    <jats:italic>TWIST1<\/jats:italic>\n                    was overexpressed in 36% of our cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200976). There was a significant positive correlation between recurrence with grade T, grade V and a significant negative correlation with growth activity. Our vast literature review on different signaling pathways in pterygium showed that EMT has centralization role in recurrence of this disease. Our data confirmed that EMT is important in the recurrence of pterygium samples and different signaling pathways end up activating the EMT markers. It is suggested to evaluate the environmental factors and their correlation with molecular markers to select favorable treatment for this kind of diseases.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28447","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T23:17:34Z","timestamp":1552000654000},"page":"18146-18155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Signaling roadmap to epithelial\u2013mesenchymal transition in pterygium,\n                    <i>TWIST1<\/i>\n                    centralized"],"prefix":"10.1002","volume":"234","author":[{"given":"Seyed Elyas","family":"Meshkani","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Kooshan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Biotechnology School of Biological Science, Varamin\u2010Pishva Branch, Islamic Azad University Varamin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo Baradaran","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Sabzevar Branch, Islamic Azad University Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Falanji","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Paramedical Sciences, Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Adli","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Baghbani\u2010Arani","sequence":"additional","affiliation":[{"name":"Department of Genetics and Biotechnology School of Biological Science, Varamin\u2010Pishva Branch, Islamic Azad University Varamin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Ghasemi","family":"Arian","sequence":"additional","affiliation":[{"name":"Arian Hospital, Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-8828","authenticated-orcid":false,"given":"Abolfazl","family":"Rad","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences Sabzevar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.01.016"},{"key":"e_1_2_9_1_3_1","first-page":"63","article-title":"Tissue factor expression in human pterygium","volume":"17","author":"Ando R.","year":"2011","journal-title":"Molecular Vision"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.03.001"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00158-1"},{"key":"e_1_2_9_1_6_1","first-page":"2015","article-title":"Tissue factor induced by epithelial\u2013mesenchymal transition triggers a pro\u2010coagulant state that drives metastasis of circulating tumor cells","volume":"2263","author":"Bourcy M.","year":"2016","journal-title":"Cancer Research, Canres"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.6064\/2012\/964862"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00439-5"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.16.3145"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1438"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2173"},{"issue":"6","key":"e_1_2_9_1_12_1","first-page":"827","article-title":"Inhibition effect of curcumin on UVB\u2010induced secretion of pro\u2010inflammatory cytokines from corneal limbus epithelial cells","volume":"10","author":"Chao S.\u2010C.","year":"2017","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10469"},{"issue":"2","key":"e_1_2_9_1_14_1","first-page":"189","article-title":"Anti\u2010fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells","volume":"11","author":"Chen Y.\u2010Y.","year":"2018","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.037"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"crossref","unstructured":"Clearfield E. 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