{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:14:29Z","timestamp":1792624469443,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,10]],"date-time":"2019-03-10T00:00:00Z","timestamp":1552176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30700852"],"award-info":[{"award-number":["30700852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272036"],"award-info":[{"award-number":["81272036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological interventions aimed at inhibiting of these pathways may be a promising approach for the management of OA. Quercetin is a member of the flavonoid family and has antioxidant and anti\u2010inflammatory properties in degenerative diseases. However, its effects and potential mechanisms on the pathological process of OA are not very clear. The present study aimed to investigate the protective effects of quercetin on OA and the underlying mechanisms. The tert\u2010butyl hydroperoxide (TBHP)\u2010stimulated rat chondrocytes and destabilization of the medial meniscus OA rat model was used to explore the protective effects of quercetin. Our results showed that\u00a0quercetin treatment can attenuate oxidative stress, ER stress, and associated apoptosis. Moreover,\u00a0quercetin inhibited ER stress through activating the sirtuin1\/adenosine monophosphate\u2010activated protein kinase (SIRT1\/AMPK) signaling pathway. The protective effects of\u00a0quercetin were also observed in OA rat model which is evidenced by abolished cartilage degeneration and decreased chondrocytes apoptosis in the knee joints. Our results suggested that\u00a0quercetin is a promising treatment for OA.<\/jats:p>","DOI":"10.1002\/jcp.28452","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:31:50Z","timestamp":1552264310000},"page":"18192-18205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":236,"title":["Quercetin attenuates oxidative stress\u2010induced apoptosis via SIRT1\/AMPK\u2010mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model"],"prefix":"10.1002","volume":"234","author":[{"given":"Kai","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Pengcheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants Ninth People's Hospital, Shanghai Jiaotong University School of Medicine Shanghai People's Republic of 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Zhang Y. Tang L. Ji Y. Yan C. &Zhang X.(2019).Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis.Drug Development Research. 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