{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:38:07Z","timestamp":1790260687173,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the relationship between prognostic nutritional index (PNI) and systemic immune\u2010inflammation index (SII) and clinical features and prognosis of osteosarcoma patients. We retrospectively investigated 126 patients with surgery for osteosarcoma between 2012 and 2018 at our hospital. The preoperative PNI was calculated as albumin level (g\/L) + 5 \u00d7 total lymphocyte count (10\n                    <jats:sup>9<\/jats:sup>\n                    \/L). The SII was defined as platelet \u00d7 neutrophil\/lymphocyte counts. The optimal cut\u2010off values for PNI and SII were evaluated with receiver operating curve analysis. Clinical features and PNI and SII were tested with the\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    test. The effects of PNI and SII on overall survival (OS) was investigated by Kaplan\u2013Meier method and Cox proportional hazards model. A low preoperative PNI was remarkably correlated with tumor size, Enneking stage, pathological fracture, local recurrence, metastasis, and neoadjuvant chemotherapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Whereas, a high SII was significantly associated with tumor size, histological type, Enneking stage, and neoadjuvant chemotherapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). There was a significant negative relationship between the PNI and SII (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.384;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). For univariate analyses, the results revealed that tumor size, local recurrence, metastasis, PNI, and SII were predictors of OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In multivariate analyses, local recurrence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010), metastasis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), PNI (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and SII (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029) as independent prognostic factors were significantly correlated with OS. This study suggested that PNI and SII could be important prognostic parameters for patients with osteosarcoma.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28476","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T01:23:46Z","timestamp":1553045026000},"page":"18408-18414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Prognostic value of prognostic nutritional index and systemic immune\u2010inflammation index in patients with osteosarcoma"],"prefix":"10.1002","volume":"234","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-0421","authenticated-orcid":false,"given":"Weiyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-1358","authenticated-orcid":false,"given":"Zengwu","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0149"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i34.6261"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.460"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040766"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132544"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4732-8"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1081\/IMM-120022979"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.04.004"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207514"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4048-0"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.183"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2330-1"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S140560"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.04.056"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0198"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39862"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"crossref","first-page":"809891","DOI":"10.1155\/2013\/809891","article-title":"Therapeutic doses of nonsteroidal anti\u2010inflammatory drugs inhibit osteosarcoma MG\u201063 osteoblast\u2010like cells maturation, viability, and biomineralization potential","volume":"2013","author":"Luna\u2010Bertos E.","year":"2013","journal-title":"The Scientific World Journal"},{"key":"e_1_2_8_1_22_1","first-page":"834246","article-title":"Effect of aspirin on cell growth of human MG\u201063 osteosarcoma line","volume":"2012","author":"Luna\u2010Bertos E.","year":"2012","journal-title":"The Scientific World Journal"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.305805.117"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24121"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0708-7"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2523-6"},{"key":"e_1_2_8_1_29_1","first-page":"1","article-title":"A prospective, randomized study of adjuvant parenteral nutrition in the treatment of sarcomas: Results of metabolic and survival studies","volume":"96","author":"Shamberger R. 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