{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:43:10Z","timestamp":1788997390930,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer stem cells (CSCs) have been recognized as the significant cause of tumor recurrence. Long noncoding RNAs (lncRNAs) are involved in various cancers, including human laryngeal cancer. So far the correlation between lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) and CSC\u2010like properties in human laryngeal cancer remains barely known. In our current study, two human larynx squamous carcinoma cell lines (Hep\u20102 and Hep\u20102R) with different radio sensitivities were cultured. Interestingly, CSC\u2010like phenotypes were much more enriched in Hep\u20102R cells. We found that DGCR5 was upregulated and microRNA\u2010506 (miR\u2010506) was downregulated in Hep\u20102R cells. In addition, silence of DGCR5 could inhibit the stemness and enhance the radiosensitivity of Hep\u20102R cells. Meanwhile, overexpression of miR\u2010506 also suppressed the CSC\u2010like traits and the radiosensitivity was increased significantly. In addition, miR\u2010506 was predicted as target of DGCR5 and the correlation between them was validated in our study. Finally, we observed that Wnt pathway exerted a significant role in human laryngeal CSCs and DGCR5 inhibition could repress Wnt signaling activity by sponging miR\u2010506. In vivo assays were performed and we found that DCGR5 depressed stemness of human laryngeal cancer cells through modulating miR\u2010506 and Wnt signaling pathway. Taken these together, we reported that DGCR5 induced CSC\u2010like properties by sponging miR\u2010506 through activating Wnt in human laryngeal carcinoma cells.<\/jats:p>","DOI":"10.1002\/jcp.28478","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T04:51:22Z","timestamp":1555131082000},"page":"18423-18431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["DGCR5 promotes cancer stem cell\u2010like properties of radioresistant laryngeal carcinoma cells by sponging miR\u2010506 via Wnt pathway"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-5980","authenticated-orcid":false,"given":"Tian","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Oncology RenMin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-6500","authenticated-orcid":false,"given":"Guang","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Oncology RenMin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23105"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091903"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.016"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26215"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0432-x"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20481"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4023-9"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452582"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq353"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.7.5.13216"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2904-y"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.006"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4219-z"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-017-2814-8"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.90"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4749-4"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2015.12.004"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5779"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1395-8"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.10.021"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192002"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26590"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.59"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065750"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X09666131217003709"},{"issue":"7","key":"e_1_2_7_1_27_1","first-page":"1963","article-title":"Long non\u2010coding RNA Dleu2 affects proliferation, migration and invasion ability of laryngeal carcinoma cells through triggering miR\u201016\u20101 pathway","volume":"22","author":"Xie Z. 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