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This study sets out to investigate whether \u03b2\u2010catenin plays a critical role in hip OA pathogenesis. Here, we showed overexpressed \u03b2\u2010catenin protein in human OA cartilage tissues. Then, we analyzed\n                    <jats:italic>\u03b2\u2010cat(ex3)<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Col2ER<\/jats:italic>\n                    <\/jats:sup>\n                    mice, in which\n                    <jats:italic>\u03b2\u2010catenin<\/jats:italic>\n                    gene was conditionally activated in femoral head chondrocytes. At 2 months of age,\n                    <jats:italic>\u03b2\u2010cat(ex3)<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Col2ER<\/jats:italic>\n                    <\/jats:sup>\n                    mice already showed a phenotype of severe cartilage degeneration in the femoral head. More changes observed in\n                    <jats:italic>\u03b2\u2010cat(ex3)<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>Col2ER<\/jats:italic>\n                    <\/jats:sup>\n                    mice with age included subchondral sclerosis and osteophyte formation along joint margins, resembling a hip OA phenotype in humans. In addition, cartilage degradation and chondrocyte apoptosis as the results of\n                    <jats:italic>\u03b2\u2010catenin<\/jats:italic>\n                    activation possibly contributed to this hip OA\u2010like phenotype. Overall our findings provide direct evidence about the importance of \u03b2\u2010catenin in hip OA pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28491","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:22:11Z","timestamp":1553559731000},"page":"18535-18543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Activation of \u03b2\u2010catenin in\n                    <i>Col2<\/i>\n                    \u2010expressing chondrocytes leads to osteoarthritis\u2010like defects in hip joint"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-4146","authenticated-orcid":false,"given":"Chenjie","family":"Xia","sequence":"first","affiliation":[{"name":"Institute of Orthopedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The First College of Clinical Medicine 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