{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:22:53Z","timestamp":1790097773303,"version":"4.0.1"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["C2017022"],"award-info":[{"award-number":["C2017022"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772806"],"award-info":[{"award-number":["31772806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute kidney injury (AKI) is a frequent and serious complication of sepsis; however, there are currently no effective therapies. Inflammation and oxidative stress are the major mechanisms implicated in lipopolysaccharide (LPS)\u2010induced AKI. Dexmedetomidine (DEX) has been reported to have remarkable anti\u2010inflammatory and antioxidant effects. Here, we examined the renoprotective effects of DEX and potential underlying mechanisms in rats with LPS\u2010induced AKI. We analyzed renal function and structure; serum inflammatory cytokine; renal oxidant and antioxidant levels; and renal expression of glycogen synthase kinase\u20103\u03b2 (GSK\u20103\u03b2)\/nuclear factor erythroid 2\u2010related factor 2 (Nrf2) pathway\u2010related proteins in rats 4\u2009hr after administration of LPS. Pretreatment with DEX improved renal function and significantly reduced the levels of inflammatory cytokines and oxidative stress markers. Treatment with DEX and the GSK\u20103\u03b2 inhibitor SB216367 promoted phosphorylation of GSK\u20103\u03b2, induced Nrf2 nuclear translocation, and increased transcription of the Nrf2 target genes heme oxygenase\u20101 and NAD(P)H quinone oxidoreductase\u20101, primarily in renal tubules. Alpha\u20102\u2010adrenergic receptor (\u03b12\u2010AR) antagonist atipamezole and imidazoline I\n                    <jats:sub>2<\/jats:sub>\n                    receptor (I\n                    <jats:sub>2<\/jats:sub>\n                    R) antagonist idazoxan reversed the effects of DEX. These results suggest that the renoprotective effects of DEX are mediated via \u03b12\u2010AR and I\n                    <jats:sub>2<\/jats:sub>\n                    R\u2010dependent pathways that reduce inflammation and oxidative stress through GSK\u20103\u03b2\/Nrf2 signaling.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28539","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T09:12:21Z","timestamp":1553764341000},"page":"18994-19009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Dexmedetomidine ameliorates lipopolysaccharide\u2010induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK\u20103\u03b2\/Nrf2 signaling pathway"],"prefix":"10.1002","volume":"234","author":[{"given":"Xiujing","family":"Feng","sequence":"first","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guan","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyu","family":"Song","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yao","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-6908","authenticated-orcid":false,"given":"Honggang","family":"Fan","sequence":"additional","affiliation":[{"name":"Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015070740"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.002"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.131"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31828fad4a"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt204"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.443"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4755-7"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37829"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20154646"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1214243"},{"key":"e_1_2_9_1_12_1","first-page":"1","article-title":"Dexmedetomidine ameliorates acute stress\u2010induced kidney injury by attenuating oxidative stress and apoptosis through inhibition of the ROS\/JNK signaling pathway","volume":"2018","author":"Chen Y.","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_9_1_13_1","first-page":"1","article-title":"Hydrogen sulfide attenuates LPS\u2010induced acute kidney injury by inhibiting inflammation and oxidative stress","volume":"2018","author":"Chen Y.","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5345"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0554-5"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.306"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/358396"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001035"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318164ca81"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4826724"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39421"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4130967"},{"issue":"3","key":"e_1_2_9_1_23_1","first-page":"3144","article-title":"Effects of dexmedetomidine pretreatment on heme oxygenase\u20101 expression and oxidative stress during one\u2010lung ventilation","volume":"8","author":"Gao S.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.001"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.142"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.04.013"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10283"},{"key":"e_1_2_9_1_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214521795"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12397"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.347"},{"key":"e_1_2_9_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.239"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002038"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15034049"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611336200"},{"key":"e_1_2_9_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.059"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1292-10.2010"},{"key":"e_1_2_9_1_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"e_1_2_9_1_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1959"},{"key":"e_1_2_9_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12728"},{"key":"e_1_2_9_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9845-x"},{"key":"e_1_2_9_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6206"},{"key":"e_1_2_9_1_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4032428"},{"key":"e_1_2_9_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.003"},{"key":"e_1_2_9_1_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00911"},{"key":"e_1_2_9_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.08.044"},{"key":"e_1_2_9_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)02001-X"},{"key":"e_1_2_9_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.07.006"},{"key":"e_1_2_9_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.001"},{"key":"e_1_2_9_1_49_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121214"},{"key":"e_1_2_9_1_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90435.2008"},{"key":"e_1_2_9_1_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6193694"},{"key":"e_1_2_9_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_9_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.05.001"},{"key":"e_1_2_9_1_54_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060672"},{"key":"e_1_2_9_1_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.439"},{"key":"e_1_2_9_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.11.034"},{"key":"e_1_2_9_1_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513737200"},{"key":"e_1_2_9_1_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.108"},{"key":"e_1_2_9_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.09.017"},{"key":"e_1_2_9_1_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164763"},{"key":"e_1_2_9_1_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00148.2011"},{"key":"e_1_2_9_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.006"},{"key":"e_1_2_9_1_63_1","first-page":"190","article-title":"Highly selective and specific antagonism of central and peripheral alpha 2\u2010adrenoceptors by atipamezole","volume":"297","author":"Virtanen R.","year":"1989","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"e_1_2_9_1_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00284.x"},{"key":"e_1_2_9_1_65_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5321"},{"key":"e_1_2_9_1_66_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009080828"},{"key":"e_1_2_9_1_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/627831"},{"key":"e_1_2_9_1_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.286"},{"key":"e_1_2_9_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.05.009"},{"key":"e_1_2_9_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2018.12.001"},{"key":"e_1_2_9_1_71_1","first-page":"1","article-title":"Dexmedetomidine pretreatment attenuates kidney injury and oxidative stress during orthotopic autologous liver transplantation in rats","volume":"2016","author":"Yu X.","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_9_1_72_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050484"},{"key":"e_1_2_9_1_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151620"},{"key":"e_1_2_9_1_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01382.x"},{"key":"e_1_2_9_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.047"},{"key":"e_1_2_9_1_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00872"},{"key":"e_1_2_9_1_77_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.6050"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:47:25Z","timestamp":1784292445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jcp.28539"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28539","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]},"assertion":[{"value":"2018-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}