{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:06:17Z","timestamp":1784293577015,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Considerable advances have been made in identification of the involvement of immune modulators in diseases. There is growing evidence on the role of complement pathway in pathogenesis and course of multiple sclerosis (MS). Moreover, it has been recognized that microRNAs (miRNAs) play an essential role in modulation and development of immune response in the central nervous system. We aimed to investigate the expression profile of complement factor H (CFH) and miR\u2010146a genes in experimental autoimmune encephalomyelitis (EAE) mouse model of MS to detect the possible roles of CFH and miR\u2010146a as biomarkers of MS disease stats. Expression of CFH and miR\u2010146a genes in liver and brain tissues of EAE mice was measured in acute and chronic phases of disease compared to matched controls using real\u2010time polymerase chain reaction. In the liver, increased expression of CFH gene was observed in the chronic phase compared to the acute phase. However, no significant difference was observed between acute and chronic phase mice with normal mice, while miR\u2010146a expression was significantly decreased in livers of EAE mice in chronic group compared to acute and control groups. The expression of CFH gene in brain had a significant decrease in acute and chronic phases compared to healthy mice. Taken together, these observations indicate probable implication of complement system and miR\u2010146a in course of immune\u2010related diseases and reveal more facts about the pathogenesis of MS. However, further work is needed to determine protein levels of CFH and other possible targets of miR\u2010146a in serum and cerebrospinal fluid of MS patients.<\/jats:p>","DOI":"10.1002\/jcp.28583","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:50:49Z","timestamp":1555005049000},"page":"19842-19851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Altered expression patterns of complement factor H and miR\u2010146a genes in acute\u2010chronic phases in experimental autoimmune encephalomyelitis mouse"],"prefix":"10.1002","volume":"234","author":[{"given":"Saba","family":"Gharibi","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Medicine, International Campus Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Moghimi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Medicine Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-4943","authenticated-orcid":false,"given":"Dariush","family":"Haghmorad","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine Semnan University of Medical Sciences Semnan Iran"},{"name":"Department of Immunology, School of Medicine Semnan University of Medical Sciences and Health Services Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Bagher","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Medicine Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensieh","family":"Shahvazian","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Medicine, International Campus Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Yadegari","sequence":"additional","affiliation":[{"name":"Department of Biology &amp; Anatomical Sciences, Shahid Sadoughi University of Medical Sciences and Health Services Faculty of Medicine Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-0626","authenticated-orcid":false,"given":"Ehsan Farashahi","family":"Yazd","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Medicine Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"},{"name":"Genetic Engineering and Genome Editing Laboratory, Stem Cell Biology Research Center Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taher","family":"Tahoori","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132815Y.0000000075"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.01.005"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010111"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101823"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30959-X"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2015.00005","article-title":"Increase in NF\u2010\u03baB\u2010sensitive miRNA\u2010146a and miRNA\u2010155 in multiple sclerosis (MS) and pro\u2010inflammatory neurodegeneration","volume":"8","author":"Devier D. 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