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In our study, we found that T helper cell 17 (Th17)\/regulatory T cell (Treg) balance is destabilized in the peripheral blood of patients with periodontitis, with upregulated Th17 or downregulated Treg, respectively.\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    lipopolysaccharide (LPS) was used to simulate the inflammatory microenvironment of chronic periodontitis. The exosomes were extracted from periodontal ligament stem cells (PDLSCs) in LPS\u2010induced periodontitis environment, which inversely effected on CD4+ T cells under normal and inflammatory conditions. Furthermore, compared with exosomes from normal PDLSCs, lower expression of microRNA\u2010155\u20105p (miR\u2010155\u20105p) and higher expression of Sirtuin\u20101 (SIRT1) were observed in exosomes from LPS\u2010stimulated PDLSCs. Exosomes from PDLSCs alleviated inflammatory microenvironment through Th17\/Treg\/miR\u2010155\u20105p\/SIRT1 regulatory network. This study aimed to find the \u201cswitching\u201d factors that affected the further deterioration of periodontitis to maximally control the multiple downstream damage signal factors to further understand periodontitis and find new targets for its treatment.\n                  <\/jats:p>","DOI":"10.1002\/jcp.28671","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T23:59:05Z","timestamp":1556063945000},"page":"20662-20674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["Exosomal microRNA\u2010155\u20105p from PDLSCs regulated Th17\/Treg balance by targeting sirtuin\u20101 in chronic periodontitis"],"prefix":"10.1002","volume":"234","author":[{"given":"Ya","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of Nantong University Nantong China"},{"name":"Research Center of Clinical Medicine Affiliated Hospital of Nantong 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