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Thus, agents or drugs which can target osteoclast development and attenuate bone loss are potentially considerable in preventing and treating of bone lytic diseases. In recent years, many studies have reported that Notch signaling has substantial impacts on the process of osteoclast differentiation, maturation, and bone destruction. In the present study, we showed that LY411575, a \u03b3\u2010secretase inhibitor, could potently suppress osteoclast differentiation, osteoclast\u2010specific gene expression, and bone resorption via suppressing Notch\/HES1\/MAPK (ERK and p38)\/Akt\u2010mediated NFATc1 induction in vitro. Consistent with in vitro results, LY411575 exhibited protective effects in lipopolysaccharides\u2010induced calvarial bone destruction in vivo. Collectively, these results indicate that LY411575 may have therapeutic potential in the treatment of osteoclast\u2010mediated osteolytic bone diseases.<\/jats:p>","DOI":"10.1002\/jcp.28699","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T01:09:29Z","timestamp":1556154569000},"page":"20944-20956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["LY411575, a potent \u03b3\u2010secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS\u2010induced calvarial osteolysis in vivo"],"prefix":"10.1002","volume":"234","author":[{"given":"Xinwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai 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