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Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells transfected with angiogenin\u20101 (Ang\u20101\u2010BMSCs) affects the damaged retinal tissue of oxygen\u2010induced retinopathy of prematurity (OIR\u2010ROP) mice. After OIR\u2010ROP mouse model establishment, Ang\u20101\u2010BMSCs, RSCs, and OIR\u2010ROP retinal tissues were cocultured in a a transwell chamber. RSCs proliferation and the expression of Ang\u20101, insulin\u2010like growth factor\u20101 (IGF\u20101) in the supernatant of RSCs, as well as \u03b2\u2010tubulin and protein kinase C (PKC) expression were evaluated. Finally, the repair of OIR\u2010ROP mice retinal tissues was observed by injecting Ang\u20101\u2010BMSCs\u2009+\u2009RSCs. In the OIR\u2010ROP mouse model, RSCs cocultured with OIR\u2010ROP retinal tissues could be induced to differentiate into cells expressing \u03b2\u2010tubulin and PKC and promote the expression of Ang\u20101 and IGF\u20101. coculture of Ang\u20101\u2010BMSCs further enhanced the proliferation and differentiation of RSCs by promoting the expression of Ang\u20101 and IGF\u20101. Coculture of RSCs\u2009+\u2009Ang\u20101\u2010BMSCs induced differentiation of Ang\u20101\u2010BMSCs through interaction among intercellular factors and restored the damaged retinal tissue of OIR\u2010ROP mice. Collectively, our study provided evidence that coculture of Ang\u20101\u2010BMSCs and RSCs could promote the proliferation and differentiation of RSCs and improve the treatment for the damaged retina tissue of OIR\u2010ROP mice.<\/jats:p>","DOI":"10.1002\/jcp.28706","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T04:38:32Z","timestamp":1558327112000},"page":"21027-21038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bone marrow mesenchymal stem cells modified by angiogenin\u20101 promotes tissue repair in mice with oxygen\u2010induced retinopathy of prematurity by promoting retinal stem cell proliferation and differentiation"],"prefix":"10.1002","volume":"234","author":[{"given":"Qian\u2010Qian","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neonatology NICU of Binzhou Medical University Hospital Binzhou People's Republic of China"},{"name":"BaYi 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