{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:26:11Z","timestamp":1787635571338,"version":"build-2736575974"},"reference-count":99,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002958","name":"Drug Applied Research Center, Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["59529"],"award-info":[{"award-number":["59529"]}],"id":[{"id":"10.13039\/501100002958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Baculoviral IAP repeat containing 5 (BIRC5) gene encodes the important protein as survivin, a multifunctional protein, which is involved in cellular and molecular networks, progression of cell cycle, homeostasis, developmental morphogenesis, and apoptosis. The proximal BIRC5 promoter possesses specific binding sites for key transcription factors such as nuclear factor \u03baB and signal transducer and activator of transcription 3. Upregulation of survivin exacerbates the autoimmune diseases (AIDs) including multiple sclerosis and myasthenia gravis by reducing the activity threshold of survivin\u2010specific cytotoxic T cells. DNA damage along with upregulation or downregulation of survivin have been demonstrated in initiation and pathogenesis of cancers and AIDs. However, detailed mechanism of survivin function in pathogenesis of AIDs is not well understood. This review focuses on the structure, specificity, regulation, and function of survivin in physiologic conditions and pathogenesis of AIDs.<\/jats:p>","DOI":"10.1002\/jcp.28725","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T01:23:22Z","timestamp":1556155402000},"page":"19440-19450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Survivin modulatory role in autoimmune and autoinflammatory diseases"],"prefix":"10.1002","volume":"234","author":[{"given":"Yasamin","family":"Pahlavan","sequence":"first","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Molecular Medicine Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Students Research Committee University of Tabriz Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"kahroba","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Molecular Medicine Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Students Research Committee University of Tabriz Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5553","authenticated-orcid":false,"given":"Nasser","family":"Samadi","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Molecular Medicine Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Biochemistry Faculty of Medicine, Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Ansarin","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Tuberculosis and Lung Disease Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-6967","authenticated-orcid":false,"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"e_1_2_12_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010010\u20109196\u20101"},{"key":"e_1_2_12_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032033"},{"key":"e_1_2_12_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-917"},{"key":"e_1_2_12_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.18.11177"},{"key":"e_1_2_12_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.033"},{"key":"e_1_2_12_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.033"},{"key":"e_1_2_12_1_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047668"},{"key":"e_1_2_12_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.007"},{"key":"e_1_2_12_1_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201007\u20102130"},{"key":"e_1_2_12_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.04.025"},{"key":"e_1_2_12_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20016"},{"key":"e_1_2_12_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.9.659"},{"key":"e_1_2_12_1_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2123"},{"key":"e_1_2_12_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010013\u20102856\u20100"},{"key":"e_1_2_12_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.021"},{"key":"e_1_2_12_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"e_1_2_12_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007\u20100027"},{"key":"e_1_2_12_1_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/152428"},{"key":"e_1_2_12_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(05)00020\u20101"},{"key":"e_1_2_12_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.11.037"},{"key":"e_1_2_12_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201000517\u2010w"},{"key":"e_1_2_12_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00724-1"},{"key":"e_1_2_12_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000468"},{"key":"e_1_2_12_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.8.2393S"},{"key":"e_1_2_12_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00006-5"},{"key":"e_1_2_12_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.11.004"},{"key":"e_1_2_12_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.10.020"},{"key":"e_1_2_12_1_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606203200"},{"key":"e_1_2_12_1_30_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1011.040367"},{"key":"e_1_2_12_1_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.3.575"},{"key":"e_1_2_12_1_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201005\u20100375"},{"key":"e_1_2_12_1_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704035200"},{"key":"e_1_2_12_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010014\u20101125\u20106"},{"key":"e_1_2_12_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.05.016"},{"key":"e_1_2_12_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.07.003"},{"key":"e_1_2_12_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.02.001"},{"key":"e_1_2_12_1_38_1","doi-asserted-by":"crossref","unstructured":"Hooper D. Spitsin S. Kean R. Champion J. Dickson G. Chaudhry I. \u2026Koprowski H.(1998). Uric acid a natural scavenger of peroxynitrite in experimental allergic encephalomyelitis and multiple sclerosisProceedings of the National Academy of Sciences95(2):675\u2010680.","DOI":"10.1073\/pnas.95.2.675"},{"key":"e_1_2_12_1_39_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0507282"},{"key":"e_1_2_12_1_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"e_1_2_12_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26949"},{"key":"e_1_2_12_1_42_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01\u20100280fje"},{"key":"e_1_2_12_1_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0113"},{"key":"e_1_2_12_1_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192606"},{"key":"e_1_2_12_1_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.12.4305"},{"key":"e_1_2_12_1_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.25"},{"key":"e_1_2_12_1_47_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091087"},{"key":"e_1_2_12_1_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.6.529"},{"key":"e_1_2_12_1_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3528"},{"key":"e_1_2_12_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/70242"},{"key":"e_1_2_12_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2009.82"},{"key":"e_1_2_12_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010017\u20109230\u20102"},{"key":"e_1_2_12_1_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780241"},{"key":"e_1_2_12_1_54_1","doi-asserted-by":"publisher","DOI":"10.5681\/apb.2013.044"},{"key":"e_1_2_12_1_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401091"},{"key":"e_1_2_12_1_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker428"},{"key":"e_1_2_12_1_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg263"},{"key":"e_1_2_12_1_58_1","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20083"},{"key":"e_1_2_12_1_59_1","doi-asserted-by":"crossref","unstructured":"McNally J. P. Millen S. H. Chaturvedi V. Lakes N. Terrell C. E. Elfers E. E. \u2026andKanter J.(2017). Manipulating DNA damage\u2010response signaling for the treatment of immune\u2010mediated diseasesProceedings of the National Academy of Sciences114(24):E4782\u2010E4791.https:\/\/doi.org\/10.1073\/pnas.1703683114.","DOI":"10.1073\/pnas.1703683114"},{"key":"e_1_2_12_1_60_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0507287"},{"key":"e_1_2_12_1_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2590"},{"key":"e_1_2_12_1_62_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297908110035"},{"key":"e_1_2_12_1_63_1","doi-asserted-by":"publisher","DOI":"10.5681\/apb.2012.013"},{"key":"e_1_2_12_1_64_1","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2016.17.11.5031"},{"key":"e_1_2_12_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00019-5"},{"key":"e_1_2_12_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38866"},{"key":"e_1_2_12_1_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.62"},{"key":"e_1_2_12_1_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009033482038"},{"key":"e_1_2_12_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.08.007"},{"key":"e_1_2_12_1_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.237586"},{"key":"e_1_2_12_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)80047\u20101"},{"key":"e_1_2_12_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00205-7"},{"key":"e_1_2_12_1_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.10.001"},{"key":"e_1_2_12_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2014.01.003"},{"key":"e_1_2_12_1_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78088"},{"key":"e_1_2_12_1_76_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141122"},{"key":"e_1_2_12_1_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"e_1_2_12_1_78_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327117730879"},{"key":"e_1_2_12_1_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12263\u2010018\u20100596\u20104"},{"key":"e_1_2_12_1_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.210.65.1"},{"key":"e_1_2_12_1_81_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.00454.x"},{"key":"e_1_2_12_1_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.7.1115"},{"key":"e_1_2_12_1_83_1","volume-title":"PCR troubleshooting and optimization. The essential guide","author":"Skovgaard N.","year":"2011"},{"key":"e_1_2_12_1_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep467"},{"key":"e_1_2_12_1_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201007\u20100494"},{"key":"e_1_2_12_1_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1998"},{"key":"e_1_2_12_1_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833ed177"},{"key":"e_1_2_12_1_88_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890903376280"},{"key":"e_1_2_12_1_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200807"},{"key":"e_1_2_12_1_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.009"},{"key":"e_1_2_12_1_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.009"},{"key":"e_1_2_12_1_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102015\u2010eular.3421"},{"key":"e_1_2_12_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20109822(00)00769\u20107"},{"key":"e_1_2_12_1_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/76838"},{"key":"e_1_2_12_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.11.013"},{"key":"e_1_2_12_1_96_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6537248","article-title":"Serum HMGB1 serves as a novel laboratory indicator reflecting disease activity and treatment response in ankylosing spondylitis patients","volume":"2016","author":"Wang C.","year":"2016","journal-title":"Journal of Immunology Research"},{"key":"e_1_2_12_1_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.152777"},{"key":"e_1_2_12_1_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311299200"},{"key":"e_1_2_12_1_99_1","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.9.3.185.3961"},{"key":"e_1_2_12_1_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2008.00885.x"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.28725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:56:30Z","timestamp":1784292990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":99,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/jcp.28725"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28725","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"assertion":[{"value":"2019-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}