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However, the underlying mechanisms and mediators remain unclear. Here, we showed that mice injected with CML\u2010derived exosomes had significant weight loss and great drop of body fat rate. In the meanwhile, we found that CML\u2010derived exosomes could be taken up by adipose tissue, and, in turn, suppressed the adipogenic ability of adipose\u2010derived mesenchymal stem cells (ADSCs). By RNA sequencing, miR\u201092a\u20103p was found highly expressed in both CML cells and the derivative exosomes. Mechanistically, miR\u201092a\u20103p inhibited adipogenesis of ADSCs via posttranscriptionally decreasing C\/EBP\u03b1 expression when transferred into the ADSCs with the exosomes, and encapsulating miR\u201092a\u20103p inhibitor into CML exosomes blocked the antiadipogenic effects of CML exosomes. In addition, we also found that miR\u201092a\u20103p was highly expressed in exosomes from some other types of cancers that cause cachexia. These results demonstrate that adipogenesis inhibition by tumor\u2010derived exosomes, mainly exosomal microRNAs like miR\u201092a\u20103p, are the main mediators for CAC.<\/jats:p>","DOI":"10.1002\/jcp.28732","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:01:22Z","timestamp":1557187282000},"page":"21274-21283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Chronic myeloid leukemia\u2010derived exosomes attenuate adipogenesis of adipose derived mesenchymal stem cells via transporting miR\u201092a\u20103p"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-2776","authenticated-orcid":false,"given":"Zhuo","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Hematology, Tangdu Hospital Fourth Military Medical University Xi'an People's Republic of 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