{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:28Z","timestamp":1786978108160,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a frequent chronic musculoskeletal disorder which lacks applicably effective therapeutic strategy. In this study, we attempted to investigate whether long noncoding RNA (lncRNA) cardiac hypertrophy\u2010related factor (CHRF) participated in mediating interleukin\u20106 (IL\u20106)\u2010induced in vitro inflammatory damages as well as the regulatory mechanisms. ATDC5 cells were stimulated with IL\u20106, and then cellular damages were evaluated on the basis of cell viability by CCK\u20108, apoptotic cells by observation with flow cytometry, apoptosis\u2010associated proteins by western blot analysis, and accumulation of inflammatory factors by quantitative reverse transcription polymerase chain reaction (RT\u2010qPCR), enzyme\u2010linked immunosorbent assay (ELISA), and western blot analysis. Then, effects of lncRNA CHRF on IL\u20106\u2010treated cells were evaluated. We further explored the downstream factor of lncRNA CHRF and demonstrated whether lncRNA CHRF functioned through the downstream factor. Afterwards, crucial signaling cascades were anatomized. We found that IL\u20106 reduced cell viability, elevated apoptosis, induced upregulation of inflammatory factors, as well as upregulated lncRNA CHRF and down\u2010regulated miR\u2010146a expression. Then, we found lncRNA CHRF overexpression aggravated IL\u20106\u2010induced alterations, and lncRNA CHRF knockdown showed the opposite effects. Furthermore, miR\u2010146a was identified to be negatively regulated by lncRNA CHRF, and its overexpression abrogated the roles of lncRNA CHRF in IL\u20106\u2010treated cells. IL\u20106\u2010induced the accumulation of I\u03baB\u03b1, p65, JAK1, and STAT3 at phosphorylated level was further facilitated by lncRNA CHRF whereas repressed by miR\u2010146a. In conclusion, lncRNA CHRF aggravated the IL\u20106\u2010induced inflammatory damages in ATDC5 cells. We further outlined a possible mechanism that through downregulating miR\u2010146a, lncRNA CHRF evoked the activation of NF\u2010\u03baB and JAK1\/STAT3 signaling cascades.<\/jats:p>","DOI":"10.1002\/jcp.28749","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T09:48:45Z","timestamp":1556272125000},"page":"21851-21859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Retracted<\/i>\n                    : Long noncoding RNA CHRF exacerbates IL\u20106\u2010induced inflammatory damages by downregulating microRNA\u2010146a in ATDC5 cells"],"prefix":"10.1002","volume":"234","author":[{"given":"Chuandong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Heze Municipal Hospital Heze China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Heze Municipal Hospital Heze China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Heze Municipal Hospital Heze China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Xinxiang Medical University Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-3775","authenticated-orcid":false,"given":"Xuefeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma &amp; Hand and Foot Surgery, Jinan Central Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.012"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08477"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0980-4"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.02.1148"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328349c2b1"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12752"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23262"},{"key":"e_1_2_10_1_9_1","first-page":"192415","article-title":"Recognition of immune response for the early diagnosis and treatment of osteoarthritis","volume":"13","author":"Kandahari A. 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