{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:19:52Z","timestamp":1769123992148,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long noncoding RNA CPS1\u2010IT1 is recently recognized as a tumor suppressor in several cancers. Here, we investigate the role of CPS1\u2010IT1 in human melanoma. Presently, our study reveals the low expression of CPS1\u2010IT1 in human melanoma tissues and cell lines, which is significantly associated with metastasis and tumor stage. Besides, the potential of CPS1\u2010IT1 as a prognosis\u2010predictor is strongly indicated. Functionally, CPS1\u2010IT1 overexpression inhibits cell migration, invasion, epithelial\u2013mesenchymal transition, and angiogenesis in melanoma cells. CYR61, an angiogenic factor that participates in tumor metastasis as well as a recognized oncogene in melanoma, is shown to be confined under CPS1\u2010IT1 overexpression in melanoma cells. Furthermore, enforced expression of Cyr61 in CPS1\u2010IT1\u2010silenced melanoma cells dramatically normalized the protein level of Cyr61 and that of its downstream targets vascular endothelial growth factor and matrix metalloproteinase\u20109, as well as the repressive effect of CPS1\u2010IT1 overexpression on melanoma cell metastasis. BRG1, a core component of SWI\/SNF complex, is implied to interact with both CPS1\u2010IT1 and Cyr61 in melanoma cells. Moreover, CPS1\u2010IT1 negatively regulates Cyr61 expression by blocking the binding of BRG1 to Cyr61 promoter. Jointly, CPS1\u2010IT1 controls melanoma metastasis through impairing Cyr61 expression via competitively binding with BRG1, uncovering a novel potential therapeutic and prognostic biomarker for patients with melanoma.<\/jats:p>","DOI":"10.1002\/jcp.28764","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T04:35:41Z","timestamp":1558413341000},"page":"22017-22027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Long noncoding RNA CPS1\u2010IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-3477","authenticated-orcid":false,"given":"Xiaobo","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiaotong University School of Medicine 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