{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:35:56Z","timestamp":1789403756434,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["SBMU"],"award-info":[{"award-number":["SBMU"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanistic target of rapamycin (mTOR) is a fundamental component of a signaling pathway that is involved in the pathogenesis of breast cancer via different mechanisms. This pathway is functionally linked with a number of small nucleolar RNA host genes (<jats:italic>SNHG<\/jats:italic>s). In the present project, we have searched for the expression quantitative trait loci (eQTLs) within <jats:italic>SNHG<\/jats:italic>s that are possibly involved in the pathogenesis of breast cancer. Following this in silico step, we have assessed expression levels of <jats:italic>mTOR<\/jats:italic> and four <jats:italic>SNHG<\/jats:italic>s in malignant and nonmalignant samples obtained from 80 patients with breast cancer. We also genotyped rs4615861 of <jats:italic>SNHG3<\/jats:italic> and rs3087978 of <jats:italic>SNHG5<\/jats:italic> in the peripheral blood of patients. <jats:italic>SNHG12<\/jats:italic> expression was not detected in any of the assessed malignant or nonmalignant tissues. So this gene was excluded from further steps. Expression of <jats:italic>mTOR<\/jats:italic> and other three long noncoding RNAs (lncRNAs) were significantly increased in the malignant tissues compared with the nonmalignant tissues. When classifying patients into down\u2010\/upregulation categorized based on the transcript levels of each gene in malignant tissue versus nonmalignant tissues, we noticed associations between expression of <jats:italic>SNHG1<\/jats:italic> and stage (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), expression of <jats:italic>SNHG5<\/jats:italic> and grade (<jats:italic>p<\/jats:italic>\u2009=\u20090.05), as well as between expression of <jats:italic>SNHG3<\/jats:italic> and history of oral contraceptive use (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). We also detected higher levels of <jats:italic>SNHG3<\/jats:italic> expression in estrogen receptor\/progesterone receptor (ER\/PR) negative tumors compared with the ER\/PR positive tumors (<jats:italic>p<\/jats:italic> \u2009=\u20090.003 and <jats:italic>p<\/jats:italic>\u2009=\u20090.01, respectively). Moreover, there was a trend toward higher expression of this lncRNA in HER2\u2010positive tumors compared with the HER2\u2010negative ones (<jats:italic>p<\/jats:italic>\u2009=\u20090.07). Combination of transcript levels of all genes could differentiate malignant tissues from nonmalignant tissues with the diagnostic power of 69% (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). The rs3087978 was associated with the expression of <jats:italic>mTOR<\/jats:italic> in malignant tissues in a way that TT and TG genotypes were associated with the higher and lower levels of expressions, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). The current study underscores the significance of <jats:italic>SNHG<\/jats:italic>s in the pathogenesis of breast cancer.<\/jats:p>","DOI":"10.1002\/jcp.28767","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T03:59:27Z","timestamp":1557201567000},"page":"22044-22056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of the expression pattern of mTOR\u2010associated lncRNAs and their genomic variants in the patients with breast cancer"],"prefix":"10.1002","volume":"234","author":[{"given":"Zahra","family":"Taherian\u2010Esfahani","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0591","authenticated-orcid":false,"given":"Mohammad","family":"Taheri","sequence":"additional","affiliation":[{"name":"Urogenital Stem Cell Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Dashti","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Kholghi\u2010Oskooei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lobat","family":"Geranpayeh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sina Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-499X","authenticated-orcid":false,"given":"Soudeh","family":"Ghafouri\u2010Fard","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010015\u20103281\u2010y"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s88037"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010016\u20103817\u20109"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8ra02090f"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"crossref","unstructured":"Clare S. 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