{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:48:19Z","timestamp":1781246899278,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The function of microRNA\u201027a (miR\u201027a) on synovial angiogenesis and chondrocyte apoptosis in rats with knee osteoarthritis (KOA) by targeting PLK2 is explored in this present study.<\/jats:p><jats:p>The rat model of KOA was conducted by anterior cruciate ligament transection. Rats were injected with miR\u201027a mimics, mimics NC, pcDNA3.1\u2010PLK2 pcDNA3.1, or RLK2 RNAi plasmid via tail vein. A series of assays were used to figure out the functions of miR\u201027a and PLK2 in synovial angiogenesis and chondrocyte apoptosis in rats with KOA. Furthermore, the putative binding site between miR\u201027a and PLK2 was determined. Downregulated miR\u201027a was found in synovial tissues and cartilage tissues of KOA rats. Upregulated miR\u201027a and downregulated PLK2 inhibited synovial injury and promoted apoptosis of synovial cells, inhibited synovial angiogenesis, inhibited cartilage injury and chondrocyte apoptosis, inhibited cartilage collagen destruction, and alleviates inflammatory injury of synovial tissue and cartilage tissue in KOA rats. Overexpression of PLK2 reverses the effect of upregulation of miR\u201027a on synovial angiogenesis and chondrocyte injury in KOA rats. Our study suggests that upregulation of miR\u201027a inhibits synovial angiogenesis and chondrocyte apoptosis in KOA rats through the inhibition of PLK2.<\/jats:p>","DOI":"10.1002\/jcp.28858","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T04:10:55Z","timestamp":1559016655000},"page":"22972-22984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Upregulation of microRNA\u201027a inhibits synovial angiogenesis and chondrocyte apoptosis in knee osteoarthritis rats through the inhibition of PLK2"],"prefix":"10.1002","volume":"234","author":[{"given":"Wenjing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province Orthopedic Hospital of Henan Province Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province Orthopedic Hospital of Henan Province Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-6850","authenticated-orcid":false,"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Weihai Central Hospital Weihai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(09)60030-3"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.02.017"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1819210"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20186997"},{"issue":"1","key":"e_1_2_8_1_6_1","first-page":"459","article-title":"Biomarker analyses of PLK isoforms in breast cancer","volume":"66","author":"Degenhardt Y Y R. 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