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In this review, we comprehensively studied published papers on <jats:italic>H. pylori<\/jats:italic> vaccines using Google Scholar and NCBI databases to gather information about vaccines against <jats:italic>H. pylori<\/jats:italic>. Considering the pivotal roles of the enzyme urease (in production of NH<jats:sub>3<\/jats:sub> and neutralization of the acidic medium of the stomach), cytotoxin\u2010associated gene A, and vacuolating cytotoxin A proteins in <jats:italic>H. pylori<\/jats:italic> infection, they could be the best candidates for the construction of recombinant vaccines. The outer membrane porins (Hop), blood group antigen\u2010binding adhesin (BabA), sialic acid\u2010binding adhesin (SabA), and outer inflammatory protein A, play significant roles in binding of bacterium to human gastric tissues, and because binding is the first step in bacterial fixation and colonization, these antigens also can be considered as suitable candidates for designing vaccines. Likely, other significant bacterial antigens, such as NapA (chemotactic factor for recruitment of human neutrophils and monocytes to the site of infection), duodenal ulcer promoting protein A (to promote duodenal ulcer), and Hsp60 (as a molecular chaperon for activation of urease enzyme), can be used in the construction of subunit vaccines. New vaccines in use currently, such as DNA vaccines and subunit vaccines, can efficiently replace the dead and attenuated vaccines. Nonetheless, the results show that urease enzyme is most used compared with bacterial components in the designing and construction of recombinant vaccines. The BabA and SabA antigens belong to the outer membrane porins family in <jats:italic>H. pylori<\/jats:italic> and are required for binding and fixation of the bacterium to the human gastric tissues.<\/jats:p>","DOI":"10.1002\/jcp.28870","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T12:35:26Z","timestamp":1560342926000},"page":"21460-21470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Potential antigen candidates for subunit vaccine development against <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1002","volume":"234","author":[{"given":"Masoud","family":"Keikha","sequence":"first","affiliation":[{"name":"Antimicrobial Resistance Research Center, Bu\u2010Ali Research Institute Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Microbiology and Virology, School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-678X","authenticated-orcid":false,"given":"Majid","family":"Eslami","sequence":"additional","affiliation":[{"name":"Cancer Research Center Semnan University of Medical Sciences Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-2195","authenticated-orcid":false,"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Immunology Semnan University of Medical Sciences Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1243-6341","authenticated-orcid":false,"given":"Abdolmajid","family":"Ghasemian","sequence":"additional","affiliation":[{"name":"Department of Biology, Tehran Central Branch Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-2885","authenticated-orcid":false,"given":"Mohsen","family":"Karbalaei","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Virology, School of Medicine Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Microbiology and Virology, School of Medicine Jiroft University of Medical Sciences Jiroft Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.04.050"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004234"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145839"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.004"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020110"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.5812\/archcid.57487"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003189"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1501-x"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i28.3071"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.06.008"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"crossref","unstructured":"Buti L. 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