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Three, six, and nine\u2010month senescence\u2010accelerated resistant 1 and senescence\u2010accelerated prone 8 (SAMP8) mice were used in the current study, to unravel potential mechanisms for dementia and explore new diagnostic approaches for AD. The amyloid\u2010\u03b2 (A\u03b240) and A\u03b242 levels were elevated in hippocampi and platelets from SAMP8, along with a reduced \u03b1\u2010secretase expression and an enhanced \u03b2\u2010secretase expression extent with age, compared to control mice. Furthermore, hippocampal A\u03b240 and A\u03b242 of SAMP8 were positively correlated with platelet of these mice with aging progression. In addition, \u03b2\u2010\u03b3\u2010secretase\u2010modulated proteolytic proceeding of amyloid precursor protein in platelet might work through the PI3K\/Akt\/GSK3\u03b2 pathway. 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