{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:20:50Z","timestamp":1791894050769,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671240"],"award-info":[{"award-number":["31671240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171141"],"award-info":[{"award-number":["31171141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exercise training mitigates cardiac pathological remodeling and dysfunction caused by myocardial infarction (MI), but its underlying cellular and molecular mechanisms remain elusive. Our present study in an in vivo rat model of MI determined the impact of post\u2010MI exercise training on myocardial fibrosis, mitochondrial biogenesis, antioxidant capacity, and ventricular function. Adult male rats were randomized into: (a) Sedentary control group; (b) 4\u2010week treadmill exercise training group; (c) Sham surgery group; (d) MI group with permanent ligation of left anterior descending coronary artery and kept sedentary during post\u2010MI period; and (e) post\u2010MI 4\u2010week exercise training group. Results indicated that exercise training significantly improved post\u2010MI left ventricular function and reduced markers of cardiac fibrosis. Exercise training also significantly attenuated MI\u2010induced mitochondrial damage and oxidative stress, which were associated with enhanced antioxidant enzyme expression and\/or activity and total antioxidant capacity in the heart. Interestingly, the adaptive activation of the SIRT1\/PGC\u20101\u03b1\/PI3K\/Akt signaling following MI was further enhanced by post\u2010MI exercise training, which is likely responsible for exercise\u2010induced cardioprotection and mitochondrial biogenesis. In conclusion, this study has provided novel evidence on the activation of SIRT1\/PGC\u20101\u03b1\/PI3K\/Akt pathway, which may mediate exercise\u2010induced cardioprotection through reduction of cardiac fibrosis and oxidative stress, as well as improvement of mitochondrial integrity and biogenesis in post\u2010MI myocardium.<\/jats:p>","DOI":"10.1002\/jcp.28939","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T04:22:07Z","timestamp":1560313327000},"page":"23705-23718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1\/PGC\u20101\u03b1\/PI3K\/Akt signaling"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7350-3974","authenticated-orcid":false,"given":"Dandan","family":"Jia","sequence":"first","affiliation":[{"name":"Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhi","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-3329","authenticated-orcid":false,"given":"Lei","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pauley Heart Center Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-6161","authenticated-orcid":false,"given":"Zhenjun","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan4935"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00858.2015"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-012-1041-3"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.044"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.68.95"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.08.004"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.036"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.04.015"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0555-4"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1325062"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486167"},{"key":"e_1_2_10_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12722"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150006"},{"key":"e_1_2_10_1_15_1","first-page":"1386","article-title":"Spontaneous delayed recovery of perfusion and contraction after the first 5 weeks after anterior infarction","volume":"90","author":"Galli M.","year":"1994","journal-title":"Evidence for the presence of hibernating myocardium in the infarcted area. Circulation"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.11.035"},{"key":"e_1_2_10_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.3.282"},{"key":"e_1_2_10_1_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310183"},{"key":"e_1_2_10_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.11.004"},{"key":"e_1_2_10_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26662"},{"key":"e_1_2_10_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.06.006"},{"key":"e_1_2_10_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00471-6"},{"key":"e_1_2_10_1_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028833"},{"key":"e_1_2_10_1_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958033"},{"key":"e_1_2_10_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00694-3"},{"key":"e_1_2_10_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231097"},{"key":"e_1_2_10_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.07.009"},{"key":"e_1_2_10_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.12.009"},{"key":"e_1_2_10_1_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00865.2013"},{"key":"e_1_2_10_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt080"},{"key":"e_1_2_10_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.013"},{"key":"e_1_2_10_1_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00822.2015"},{"key":"e_1_2_10_1_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.489716"},{"key":"e_1_2_10_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9705-5"},{"key":"e_1_2_10_1_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00755.2009"},{"key":"e_1_2_10_1_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2011-1424"},{"key":"e_1_2_10_1_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S157584"},{"key":"e_1_2_10_1_38_1","first-page":"1261","article-title":"Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPARgamma and Bcl2 in model mice","volume":"17","author":"Meng C.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_10_1_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.o29"},{"key":"e_1_2_10_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(03)00145-7"},{"key":"e_1_2_10_1_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.825371"},{"key":"e_1_2_10_1_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00263.2007"},{"key":"e_1_2_10_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26799"},{"key":"e_1_2_10_1_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01092.2017"},{"key":"e_1_2_10_1_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000373937"},{"key":"e_1_2_10_1_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004397"},{"key":"e_1_2_10_1_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481876"},{"key":"e_1_2_10_1_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.090266"},{"key":"e_1_2_10_1_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609554200"},{"key":"e_1_2_10_1_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430342"},{"key":"e_1_2_10_1_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-017-0576-y"},{"key":"e_1_2_10_1_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.4.1462"},{"key":"e_1_2_10_1_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.591"},{"key":"e_1_2_10_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700928"},{"key":"e_1_2_10_1_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315604311"},{"key":"e_1_2_10_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.025"},{"key":"e_1_2_10_1_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491893"},{"key":"e_1_2_10_1_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008024"},{"key":"e_1_2_10_1_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050400"},{"key":"e_1_2_10_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.10.004"},{"key":"e_1_2_10_1_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12709"},{"key":"e_1_2_10_1_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00505"},{"key":"e_1_2_10_1_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020417"},{"key":"e_1_2_10_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.07.009"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.28939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.28939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T11:09:05Z","timestamp":1736420945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.28939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/jcp.28939"],"URL":"https:\/\/doi.org\/10.1002\/jcp.28939","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"assertion":[{"value":"2019-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}