{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:18Z","timestamp":1791571818752,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701231"],"award-info":[{"award-number":["81701231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["16ZR1431500"],"award-info":[{"award-number":["16ZR1431500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer's disease (AD) is a progressive and age\u2010related neurological dysfunction. Abundant data have profiled microRNA (miR) patterns in healthy, aging brain, and in the moderate and late\u2010stages of AD. Herein, this study aimed to explore whether miR\u2010326 could influence neuron apoptosis in AD mice and how miR\u2010326 functions in this process. The candidate differentially expressed gene <jats:italic>VAV1<\/jats:italic> was obtained by microarray analysis, and miRNAs that could regulate <jats:italic>VAV1<\/jats:italic> candidate gene were predicted. Luciferase activity determination confirmed <jats:italic>VAV1<\/jats:italic> as a target gene of miR\u2010326. AD mice models were established for investigating the effect of miR\u2010326 on AD mice. The overexpression of miR\u2010326 contributed to decreased time of the mice to find the platform and the escape latency and increased residence time on the target area. Besides, elevation of miR\u2010326 decreased A\u03b2 deposition and contents of A\u03b2<jats:sub>1\u201340<\/jats:sub> and A\u03b2<jats:sub>1\u201342<\/jats:sub>. Moreover, miR\u2010326 overexpression increased neuron cell ability, mediated cell entry, and inhibited neuron apoptosis via JNK signaling pathway. Of crucial importance, miR\u2010326 negatively regulated the expression of <jats:italic>VAV1<\/jats:italic>, inhibited tau phosphorylation, and blocked the activation of the JNK signaling pathway. Taken together these observations, we demonstrate that miR\u2010326 improves cognitive function of AD mice and inhibits neuron apoptosis in AD mice through inactivation of the JNK signaling pathway by targeting <jats:italic>VAV1<\/jats:italic>. Based on those findings, miR\u2010326 might exert promise as target for the treatment of AD.<\/jats:p>","DOI":"10.1002\/jcp.28988","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T04:09:47Z","timestamp":1565064587000},"page":"480-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["MicroRNA\u2010326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting <i>VAV1<\/i> in Alzheimer's disease"],"prefix":"10.1002","volume":"235","author":[{"given":"Bin","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Shanghai University of Medicine &amp; Health Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai University of Medicine &amp; Health Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Pudong New Area People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wusong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Pudong New Area People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-6396","authenticated-orcid":false,"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Pudong New Area People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo3007418"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.06.009"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.07.006"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322663"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.013"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01457-X"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.04.015"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7027380"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3722"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088022"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.06.012"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2002-4302"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.172"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6579"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0936-y"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.927"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.24.18160"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3424"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2004.01429.x"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4966-09.2009"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-196709"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3471"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0165"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426221"},{"key":"e_1_2_9_1_27_1","first-page":"327","article-title":"Studying micro RNA function and dysfunction in Alzheimer's disease","volume":"3","author":"Lukiw W. 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