{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:32:32Z","timestamp":1779121952520,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dilated cardiomyopathy (DCM) is a heart disease that injured greatly to the people wordwide. Systemic co\u2010expression analysis for this cancer is still limited, although massive clinic experiments and gene profiling analyses had been well performed previously. Here, using the public RNA\u2010Seq data \u201cGSE116250\u201d and gene annotation of Ensembl database, we built the co\u2010expression modules for DCM by Weighted Gene Co\u2010Expression Network Analysis, and investigated the function enrichment and protein\u2010protein interaction (PPI) network of co\u2010expression genes of each module by Database for Annotation, Visualization, and Integrated Discovery and Search Tool for the Retrieval of Interacting Genes\/Proteins database, respectively. First, 5,000 genes in the 37 samples were screened and 11 co\u2010expression modules were conducted. The number of genes for each module ranged from 77 to 936, with a mean of 455. Second, interaction relationships of hub\u2010genes between pairwise modules showed great differences, suggesting relatively high\u2010scale independence of the modules. Third, functional enrichments of the co\u2010expression modules exhibited great differences. We found that genes in module 3 were significantly enriched in the pathways of focal adhesion and ubiquitin\u2010mediated proteolysis. This module was inferred as the key module involved in DCM. In addition, PPI analysis revealed that the genes <jats:italic>HSP90AA1, CTNNB1, MAPK1, GART<\/jats:italic>, and <jats:italic>PPP2CA<\/jats:italic> owned the largest number of adjacency genes, unveiling that they may function importantly during the occurrence of DCM. Focal adhesion and ubiquitin\u2010mediated proteolysis play important roles in human DCM.<\/jats:p>","DOI":"10.1002\/jcp.28989","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:31:27Z","timestamp":1561487487000},"page":"494-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Co\u2010expression analysis provides important module and pathways of human dilated cardiomyopathy"],"prefix":"10.1002","volume":"235","author":[{"given":"Junhui","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Huadu District People's Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Huadu District People's Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianzhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Huadu District People's Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-6488","authenticated-orcid":false,"given":"Xue\u2010Feng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-5543","authenticated-orcid":false,"given":"Zun\u2010Ping","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"e_1_2_6_1_2_1","first-page":"25","article-title":"Gene ontology: Tool for the unification of biology","volume":"25","author":"Ashburner M.","year":"2000","journal-title":"The Gene Ontology Consortium"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401900101"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5202"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-300"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162669"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9493"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.046"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608396103"},{"issue":"15","key":"e_1_2_6_1_10_1","first-page":"e1","article-title":"2009 focused update incorporated into the ACC\/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"53","author":"Hunt S. 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