{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:49:07Z","timestamp":1793022547831,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81722014"],"award-info":[{"award-number":["81722014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic variation is considered to affect the <jats:italic>N<\/jats:italic><jats:sup>6<\/jats:sup>\u2010methyladenosine (m6A) RNA transcript\u00a0modification, which is the\u00a0most prevalent posttranscriptional messenger RNA modification. This study aimed to identify m6A\u2010associated single\u2010nucleotide polymorphisms (m6A\u2010SNPs) that may affect m6A methylation from numerous periodontitis (PD) SNPs. We identified an abundance of m6A\u2010SNPs by analyzing raw data of published PD genome\u2010wide association studies and m6A\u2010SNPs list from the m6AVar database. Other evidence was found in public databases for expression quantitative trait loci (eQTL) and differential gene expression analysis. Accordingly, 1938 m6A\u2010SNPs were identified, 104 of which appeared to be associated with PD (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) while 65 showed eQTL signals. Lastly, the leading SNP rs2723183 (<jats:italic>p<\/jats:italic>\u2009=\u20093.93E\u221207) was predicted to regulate local gene <jats:italic>IL\u201037<\/jats:italic> expression in PD (<jats:italic>p<\/jats:italic>\u2009=\u20092.64E\u221205; in GSE10334) and change regulatory motif RXRA. In summary, dozens of PD\u2010associated m6A\u2010SNPs were identified and their possible functions were demonstrated in this study.<\/jats:p>","DOI":"10.1002\/jcp.29005","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T07:09:06Z","timestamp":1561619346000},"page":"900-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["In silico genome\u2010wide identification of m6A\u2010associated SNPs as potential functional variants for periodontitis"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-213X","authenticated-orcid":false,"given":"Weimin","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu 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Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Department of Oral Implantology, West China Hospital of Stomatology Sichuan University  Chengdu 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