{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:39:27Z","timestamp":1785937167757,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National science foundation of China youth fund","award":["81700693"],"award-info":[{"award-number":["81700693"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emerging evidence has indicated that long noncoding RNA (lncRNAs) play crucial roles in regulating thyroid cancer (TC) development. Linc00210 is a newly identified lncRNA which plays an oncogenic role in hepatocellular carcinoma and nasopharyngeal carcinoma, but whether Linc00210 can modulate the development of TC remains elusive. Here, we found that Linc00210 expression was upregulated in TC tissues compared to the matched noncancerous tissues. Overexpression of Linc00210 augmented the proliferation, migration, and invasion of TC cells. Mechanistically, Linc00210 served as a sponge for miR\u2010195\u20105p, thereby counteracting its ability in downregulating the expression of IGF1R and the activation of PI3K\/Akt signaling. Moreover, inhibition of Linc00210 suppressed the growth of TC cells in nude mice. Our findings for the first time uncovered the oncogenic property of Linc00210 in TC.<\/jats:p>","DOI":"10.1002\/jcp.29016","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:15Z","timestamp":1561507215000},"page":"1001-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Linc00210 enhances the malignancy of thyroid cancer cells by modulating miR\u2010195\u20105p\/IGF1R\/Akt axis"],"prefix":"10.1002","volume":"235","author":[{"given":"Peijie","family":"Du","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xialian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-286X","authenticated-orcid":false,"given":"Guijun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010785"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.1000\u20109604.2015.01.06"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100962\u20106"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412569200"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08\u20102286"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485971"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1613118"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010018\u20100783\u20103"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.05.011"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611526200"},{"key":"e_1_2_11_1_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010017\u20100666\u20102"},{"key":"e_1_2_11_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.05.151"},{"key":"e_1_2_11_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/Ncomms14422"},{"key":"e_1_2_11_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.07.008"},{"issue":"3","key":"e_1_2_11_1_16_1","first-page":"128","article-title":"An overview of currently available anti\u2010insulin\u2010like growth factor I receptor antibodies","volume":"1","author":"Kusada Y.","year":"2007","journal-title":"Bioscience Trends"},{"key":"e_1_2_11_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx047"},{"key":"e_1_2_11_1_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19281"},{"issue":"5","key":"e_1_2_11_1_19_1","first-page":"2181","article-title":"The lncRNA n340790 accelerates carcinogenesis of thyroid cancer by regulating miR\u20101254","volume":"9","author":"Li Q.","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_1_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010018\u20100950\u20109"},{"key":"e_1_2_11_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1627"},{"key":"e_1_2_11_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.07.101"},{"key":"e_1_2_11_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.142"},{"key":"e_1_2_11_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614265114"},{"key":"e_1_2_11_1_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7040884"},{"key":"e_1_2_11_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.07.020"},{"key":"e_1_2_11_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)30089\u20104"},{"key":"e_1_2_11_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/Cco.0000000000000148"},{"key":"e_1_2_11_1_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7378148"},{"key":"e_1_2_11_1_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4524"},{"key":"e_1_2_11_1_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181168"},{"key":"e_1_2_11_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28072"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.29016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.29016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T08:13:45Z","timestamp":1757060025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.29016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jcp.29016"],"URL":"https:\/\/doi.org\/10.1002\/jcp.29016","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]},"assertion":[{"value":"2018-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}