{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:25:43Z","timestamp":1772306743119,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After withdrawal of liver toxic insult, the spontaneous regenerative potential of the liver is well reported in the literature. On the other hand, various molecules have been reported to promote as well as delay such natural regeneration. This current study investigates the involvement of arsenic trioxide (ATO) medication at chemotherapeutic dose on the spontaneous regeneration of the CCl<jats:sub>4<\/jats:sub> induced fibrotic liver. Liver injury markers, such as albumin and SGOT, SGPT, and ALP activities, in serum indicated that ATO supplementation during liver regeneration hampers the rejuvenation process. The hepatic architecture as well as the degree of fibrosis by hematoxylin and eosin and Sirius red staining confirms the above findings. The reduced hepatic antioxidant system and elevated oxidative stress markers, such as lipid peroxidation and 8\u2010hydroxy deoxy\u2010guanosine\u2010positive hepatocytes in ATO supplied rats, display\u00a0the persistence of oxidative stress when compared with healthy controls and the normal regeneration model. Immuno\u2010histochemical localization of Ki\u201067 indicates that mitotically active hepatocytes were fewer\u00a0in the ATO given rats when compared with normal regeneration rats. Further delay in hepatic fibrinolysis was monitored by matrix metalloproteinase zymography assay in the ATO\u2010given animals. Poly(ADP\u2010ribose) polymerase 1 expression demonstrates elevated hepatocyte apoptosis with\u00a0ATO. Furthermore, increased \u03b1\u2010smooth muscle actin indicates that the stellate cells are in an activated state in ATO supplemented fibrotic animals. In conclusion, it's observed that ATO supplementation to the fibrotic liver delays oxidative stress revitalization and maintains\u00a0stellate cells in the active form, thereby delaying\u00a0liver regeneration, and the health status of the liver must be taken into account before administering drugs like ATO.<\/jats:p>","DOI":"10.1002\/jcp.29037","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T09:08:14Z","timestamp":1562231294000},"page":"1222-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Arsenic trioxide, a cancer chemo drug hampers fibrotic liver regeneration by interrupting oxidative stress rekindling and stellate cell rejuvenation"],"prefix":"10.1002","volume":"235","author":[{"given":"Subramaniyam","family":"Nithyananthan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Pondicherry University  Puducherry 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