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Vascular endothelial growth factor receptor 2 (VEGFR2) and fibroblast growth factor receptor 1 (FGFR1) contribute to the pathogenesis of CNV. Brivanib is an oral selective dual receptor tyrosine kinase (RTK) inhibitor of FGFRs and VEGFRs, especially VEGFR2 and FGFR1. In this study, brivanib inhibited zebrafish embryonic angiogenesis without impairing neurodevelopment. In a mouse CNV model, brivanib intravitreal injection blocked phosphorylation of FGFR1 and VEGFR2 and reduced CNV leakage, area, and formation without causing intraocular toxicity. Moreover, brivanib oral gavage reduced CNV leakage and area. Accordingly, brivanib remained at high concentrations (above 14,000\u2009ng\/ml) in retinal\/choroidal\/scleral tissues following intravitreal injection. Similarly, brivanib remained at high concentrations (over 10,000\u2009ng\/ml) in retinal\/choroidal\/scleral tissues following oral gavage. Finally, in vitro cell experiments demonstrated that brivanib inhibited the proliferation, migration and tube formation of microvascular endothelial cells. In conclusion, our study suggested that brivanib treatment could be a novel therapeutic strategy for nAMD.<\/jats:p>","DOI":"10.1002\/jcp.29041","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T09:08:58Z","timestamp":1562231338000},"page":"1259-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Brivanib, a multitargeted small\u2010molecule tyrosine kinase inhibitor, suppresses laser\u2010induced CNV in a mouse model of neovascular AMD"],"prefix":"10.1002","volume":"235","author":[{"given":"Lele","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Affiliated Hospital of Nantong University  Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Lixiang Eye Hospital of Soochow University  Suzhou Jiangsu 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