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In the present study, we first determined the utility of intermittent PTH treatment in a streptozotocin\u2010induced T1D mouse model. It was shown that the PTH\u2010induced anabolic effects on bone mass and bone formation were attenuated in T1D mice compared with nondiabetic mice. Further, PTH treatment failed to activate \u03b2\u2010catenin signaling in osteoblasts of T1D mice and was unable to improve osteoblast proliferation and differentiation. Next, the Col1\u20133.2\u2009kb\u2010CreERTM; \u03b2\u2010cateninfx(ex3) mice were used to conditionally activate \u03b2\u2010catenin in osteoblasts by injecting tamoxifen, and we addressed whether or not preactivation of \u03b2\u2010catenin boosted the anabolic action of PTH on T1D\u2010related bone loss. The results demonstrated that pretreatment with activation of osteoblastic \u03b2\u2010catenin followed by PTH treatment outperformed PTH or \u03b2\u2010catenin activation monotherapy and led to greatly improved bone structure, bone mass, and bone strength in this preclinical model of T1DM. Further analysis demonstrated that osteoblast proliferation and differentiation, as well as osteoprogenitors in the marrow, were all improved in the combination treatment group. These findings indicated a clear advantage of developing \u03b2\u2010catenin as a target to improve the efficacy of PTH in the treatment of T1D\u2010related osteopenia.<\/jats:p>","DOI":"10.1002\/jcp.29068","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T02:25:33Z","timestamp":1562984733000},"page":"1480-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preactivation of \u03b2\u2010catenin in osteoblasts improves the osteoanabolic effect of PTH in type 1 diabetic mice"],"prefix":"10.1002","volume":"235","author":[{"given":"Sixu","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Department of War Wound Rescue Skills Training, Base of Army Health Service Training Army Medical University  Chongqing China"},{"name":"Department of Orthopedics The 118th Hospital of the Chinese People's Liberation Army  Zhejiang 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