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The migration and invasion potential of GBC severely affects the prognosis of patients with GBC. Glycochenodeoxycholate (GCDC) is one of the most important components in GBC\u2010associated microenvironment. However, the role of GCDC in the metastatic feature of GBC cells is not fully understood. First, the results of this study found that GCDC could effectively enhance the metastasis of GBC cells. Furthermore, GCDC could lead to the enhancement of epithelial to mesenchymal transition (EMT) phenotype in GBC cells, which is concerned to be an important mechanism of tumor metastasis. Further studies showed that GCDC treatment induced the upregulation of matrix metalloproteinase\u20103 (MMP3), MMP9, and SOCS3\/JAK2\/p\u2010STAT3 signal pathway in GBC cells, which could regulate the level of EMT. Beside that, we also found the positive\u00a0expression of farnesoid X receptor (FXR) in GBC cells and inhibition of FXR could significantly block the effect of GCDC on the metastasis of GBC cells. These results indicated that GCDC promoted GBC cells metastasis by enhancing the level of EMT and inhibition of FXR could significantly block the effect of GCDC. On one hand, FXR might be an indicator for predicting the metastasis of patient with GBC. On the other hand, FXR might serve as a potential antimetastasis target in GBC therapy.<\/jats:p>","DOI":"10.1002\/jcp.29080","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:34:44Z","timestamp":1564101284000},"page":"1615-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Glycochenodeoxycholate promotes the metastasis of gallbladder cancer cells by inducing epithelial to mesenchymal transition via activation of SOCS3\/JAK2\/STAT3 signaling pathway"],"prefix":"10.1002","volume":"235","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-5242","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P.R. 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