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Rheumatoid arthritis fibroblast\u2010like synoviocytes (RA\u2010FLSs) are of significance in the pathogenesis of RA. In this study, three microarray profiles (GSE55457, GSE55584, and GSE55235) of human joint FLSs from 33 RA patients and 20 normal controls were extracted from the Gene Expression Omnibus Dataset and analyzed to investigate the underlying pathogenesis of RA. As analyzed by the differently expressed genes, gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway enrichment, and protein\u2010protein interaction network analysis, syndecan\u20104 (SDC4), a receptor of multiple cytokines and chemokines, which played a key role in the regulation of inflammatory response, was found to be an essential regulator in RA. To further validate these results, the levels of SDC4, reactive oxygen species (ROS), nitric oxide (NO), inflammation, and apoptosis in RA\u2010FLSs were examined. SDC4\u2010silenced RA\u2010FLSs were also used. The results demonstrated that SDC4 and the level of ROS, NO, and inflammation were highly expressed while the apoptosis was decreased in RA\u2010FLSs compared with normal FLSs. SDC4 silencing significantly suppressed the levels of ROS, NO, and inflammation; elevated the expression of nuclear factor erythroid 2\u2010related factor 2; and promoted the apoptosis of RA\u2010FLSs. Collectively, our results demonstrated a new mechanism of SDC4 in initiating the inflammation and inhibiting the apoptosis of RA\u2010FLSs and that a potential target for the diagnosis and treatment of RA in the clinic might be developed.<\/jats:p>","DOI":"10.1002\/jcp.29093","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T02:18:45Z","timestamp":1563243525000},"page":"1746-1758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Syndecan\u20104 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast\u2010like synoviocytes"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-1220","authenticated-orcid":false,"given":"Peian","family":"Cai","sequence":"first","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First 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