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Cannabinoid receptor 1 (CB1) mediates the recruitment of BMMs into the injured liver. In this study, we revealed the molecular mechanisms under CB1\u2010mediated BMM infiltration. Carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) was employed to induce mouse liver injury. In vivo, human antigen R (HuR) was upregulated in macrophages of injured liver. HuR messenger RNA (mRNA) expression was positively correlated with CB1 and F4\/80 mRNA expression. Furthermore, we detected the binding between HuR and CB1 mRNA in CCl<jats:sub>4<\/jats:sub>\u2010treated livers. In vitro, HuR modulated arachidonyl\u20102\u2032\u2010chloroethylamide (ACEA, CB1 agonist)\u2010induced BMM migration by regulating CB1 expression. HuR promoted CB1 expression via binding to CB1 mRNA. ACEA promoted the association between HuR and CB1 mRNA via inducing HuR nucleoplasmic transport. In the cytoplasm, HuR competed with the miR\u201029 family to improve CB1 expression and BMM migration. In conclusion, our results prove that HuR regulates CB1 expression and influences ACEA\u2010induced BMM migration by competing with miR\u201029 family.<\/jats:p>","DOI":"10.1002\/jcp.29157","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T04:58:57Z","timestamp":1568005137000},"page":"2532-2544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Both HuR and miR\u201029s regulate expression of CB1 involved in infiltration of bone marrow monocyte\/macrophage in chronic liver injury"],"prefix":"10.1002","volume":"235","author":[{"given":"Na","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University  Beijing 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