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We studied the effect of aspirin on titanium (Ti)\u2010particle\u2010induced osteolysis in vivo and in vitro using male C57BL\/6J mice randomized to sham (sham surgery), Ti (Ti particles), low\u2010dose aspirin (Ti\/5\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7d<jats:sup>\u22121<\/jats:sup> aspirin), and high\u2010dose aspirin (Ti\/30\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7d<jats:sup>\u22121<\/jats:sup> aspirin). After 2 weeks, a three\u2010dimensional reconstruction evaluation using micro\u2010computed tomography and histomorphology assessment were performed on murine calvariae. Murine hematopoietic macrophages and RAW264.7 lineage cells were studied to investigate osteoclast formation and function. Aspirin attenuated Ti\u2010particle\u2010induced bone erosion and reduced osteoclasts. In vitro, aspirin suppressed osteoclast formation, osteoclastic\u2010related gene expression, and osteoclastic bone erosion in a dose\u2010dependent manner. Mechanically, aspirin reduced osteoclast formation by suppressing receptor activator of nuclear factor kappa\u2010B ligand\u2010induced activation of extracellular signal\u2010related kinase, p\u201038 mitogen\u2010activated protein kinase, and c\u2010Jun N\u2010terminal kinase. Thus, aspirin may be a promising option for preventing and curing osteoclastic bone destruction, including peri\u2010implant osteolysis.<\/jats:p>","DOI":"10.1002\/jcp.29164","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T14:09:51Z","timestamp":1568038191000},"page":"2599-2608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aspirin inhibits osteoclast formation and wear\u2010debris\u2010induced bone destruction by suppressing mitogen\u2010activated protein kinases"],"prefix":"10.1002","volume":"235","author":[{"given":"Jiawei","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Suzhou Kowloon hospital  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jining","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Orthopedic Institute Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-2535","authenticated-orcid":false,"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2170"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-017-0006-3"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs591"},{"key":"e_1_2_9_1_5_1","first-page":"925","article-title":"[Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]","volume":"91","author":"Chen Z. 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