{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:17:54Z","timestamp":1773868674469,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Science and Technology Project of Henan Province","award":["201503181"],"award-info":[{"award-number":["201503181"]}]},{"name":"Science and Technology Project of Science and Technology Department of Henan Province","award":["112102310072"],"award-info":[{"award-number":["112102310072"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The patients suffering from myocardial infarction (MI) undergo cardiac remodeling with the features of expanded myocardial infarct size and dilated left ventricle. Multiple microRNAs (miRNAs) are emerged as crucial modulators to participate in the remodeling process. This study is mainly intended to clarify the regulatory mechanism of miR\u2010132 in the MI\u2010induced myocardial remodeling. miR\u2010132 low expression, while interleukin\u20101\u03b2 (IL\u20101\u03b2) high expression was determined in MI by reverse\u2010transcription quantitative polymerase chain reaction and ELISA assays. MI rats showed decreased cardiac function and increased cardiomyocyte apoptosis. Moreover, miR\u2010132 and IL\u20101\u03b2 levels were altered in cardiomyocytes to explore their role in MI, with levels of proapoptotic or antiapoptotic proteins in MI together with cardiac function indexes observed. In addition, upregulation of miR\u2010132, decreased levels of Bax and Cleaved Caspase\u20103, increased left ventricular ejection fraction, left ventricular fractional shortening, the maximum rate of rise or decrease of left ventricular pressure (\u00b1dp\/dt<jats:sub>max<\/jats:sub>), and Bcl\u20102 level, which could be reversed by overexpressing IL\u20101\u03b2. All in all, miR\u2010132 inhibits cardiomyocyte apoptosis so as to ameliorate myocardial remodeling in rats with MI through IL\u20101\u03b2 downregulation. Thus, miR\u2010132 is a potential candidate for the MI treatment.<\/jats:p>","DOI":"10.1002\/jcp.29175","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T09:36:42Z","timestamp":1571305002000},"page":"2710-2721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["microRNA\u2010132 inhibits cardiomyocyte apoptosis and myocardial remodeling in myocardial infarction by targeting IL\u20101\u03b2"],"prefix":"10.1002","volume":"235","author":[{"given":"Zonglei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology Henan Provincial People's Hospital (Zhengzhou University People's Hospital)  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology Henan Provincial People's Hospital (Zhengzhou University People's Hospital)  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Henan Provincial People's Hospital (Zhengzhou University People's Hospital)  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-2649","authenticated-orcid":false,"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Henan Provincial People's Hospital (Zhengzhou University People's Hospital)  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"issue":"8","key":"e_1_2_11_2_1","first-page":"909","article-title":"MicroRNA\u2010132\u2010mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis","volume":"16","author":"Anand S.","year":"2010","journal-title":"Nature Medicine (New York, NY, United States)"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1591-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2015.0067"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.207"},{"issue":"12","key":"e_1_2_11_6_1","first-page":"4799","article-title":"Short\u2010term pretreatment with atorvastatin attenuates left ventricular dysfunction, reduces infarct size and apoptosis in acute myocardial infarction rats","volume":"7","author":"Chen T. L.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.027"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.039008"},{"issue":"5","key":"e_1_2_11_9_1","first-page":"1054","article-title":"Implication of peripheral blood miRNA\u2010124 in predicting acute myocardial infarction","volume":"21","author":"Guo M. L.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000465"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2014.8.4.391"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09653"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000258197"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2013.11.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.89"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02517.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.4.503"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i5.243"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2995"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-10-11"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09783"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017442"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.069831"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.199"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181c87e53"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.October.5.14"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1766"},{"issue":"11","key":"e_1_2_11_28_1","first-page":"13806","article-title":"Influence of interleukin\u20101 beta gene polymorphisms on the risk of myocardial infarction and ischemic stroke at young age in vivo and in vitro","volume":"8","author":"Yang B.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.10.013"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.959841"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.29175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.29175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.29175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:00:46Z","timestamp":1712754046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.29175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/jcp.29175"],"URL":"https:\/\/doi.org\/10.1002\/jcp.29175","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]},"assertion":[{"value":"2019-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}