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Emerging studies demonstrated that JNK\u2010IN\u20108 (a JNK inhibitor with high specificity) regulates traumatic brain injury through controlling neuronal apoptosis and inflammation. However, the function of JNK\u2010IN\u20108 in ischemic stroke and the mechanisms underlying of JNK\u2010IN\u20108 about neuroprotection are not well understood. In this work, male rats were treated with JNK\u2010IN\u20108 after transient middle cerebral artery occlusion, and then the modified improved neurological function score (mNSS), the foot\u2010fault test (FFT), interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106, and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) levels were assessed. We found that JNK\u2010IN\u20108\u2010treated rats with MCAO exerted an observable melioration in space learning as tested by the improved mNSS, and showed sensorimotor functional recovery as measured by the FFT. JNK\u2010IN\u20108 also played anti\u2010inflammatory roles as indicated through decreased activation of microglia and decreased IL\u20106, IL\u20101\u03b2, and TNF\u2010\u03b1 expression. Furthermore, JNK\u2010IN\u20108 suppressed the activation of JNK and nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling as indicated by the decreased level of phosphorylated\u2010JNK and p65. All data demonstrate that JNK\u2010IN\u20108 inhibits neuroinflammation and improved neurological function by inhibiting JNK\/NF\u2010\u03baB and is a promising agent for the prevention of ischemic brain injury.<\/jats:p>","DOI":"10.1002\/jcp.29183","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T23:47:02Z","timestamp":1569023222000},"page":"2792-2799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["JNK\u2010IN\u20108, a c\u2010Jun N\u2010terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke"],"prefix":"10.1002","volume":"235","author":[{"given":"Jianjian","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Diagnosis and Treatment of Severe Hepato\u2010Pancreatic Diseases The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxue","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchang","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-3036","authenticated-orcid":false,"given":"Wujun","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70235-1"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.02.033"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-54"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098367"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.03.004"},{"issue":"4","key":"e_1_2_9_1_7_1","first-page":"651","article-title":"The c\u2010Jun N\u2010terminal kinase pathway and apoptotic signaling (review)","volume":"16","author":"Chen Y. 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