{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:21:37Z","timestamp":1787574097139,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801503"],"award-info":[{"award-number":["81801503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>lncrps25<\/jats:italic>\n                    is an intergenic long noncoding RNA (lncRNA), which is location close to\n                    <jats:italic>rps25<\/jats:italic>\n                    (ribosomal protein S25) gene, is reported share high conserved sequence with NREP (neuronal regeneration\u2010related protein) 3\u2032\u2010untranslated region. The function and mechanism of most of the lncRNA in embryo development remain largely unknown. In zebrafish,\n                    <jats:italic>lncrps25<\/jats:italic>\n                    is widely expressed in the early embryonic stage and spinal cord during development. Morpholino (MO) knockdown of zebrafish\n                    <jats:italic>lncrps25<\/jats:italic>\n                    exhibit locomotor behavior defects, caused by abnormal development of motor neurons. In addition, the defect of swimming ability and motor neurons could be recovery by microinject with\n                    <jats:italic>lncrps25<\/jats:italic>\n                    RNA in\n                    <jats:italic>lncrps25<\/jats:italic>\n                    morphants. By performing RNA sequencing and quantitative real\u2010time polymerase chain reaction, we found that\n                    <jats:italic>olig2<\/jats:italic>\n                    (oligodendrocyte transcription factor 2) messenger RNA (mRNA) was downregulated in\n                    <jats:italic>lncrps25<\/jats:italic>\n                    morphants. Moreover, overexpression of\n                    <jats:italic>olig2<\/jats:italic>\n                    mRNA in\n                    <jats:italic>lncrps25<\/jats:italic>\n                    morphants partially rescued motor neurons development. Taken together, these results indicate that\n                    <jats:italic>lncrps25<\/jats:italic>\n                    plays an essential role in the development of motor neurons in zebrafish.\n                  <\/jats:p>","DOI":"10.1002\/jcp.29237","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:52:05Z","timestamp":1569286325000},"page":"3485-3496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>lncrps25<\/i>\n                    play an essential role in motor neuron development through controlling the expression of\n                    <i>olig2<\/i>\n                    in zebrafish"],"prefix":"10.1002","volume":"235","author":[{"given":"Tianheng","family":"Gao","sequence":"first","affiliation":[{"name":"College of Oceanography Hohai University  Nanjing 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