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Mesenchymal stem\/stromal cells (MSCs) are the choice of the cells for gene and cell therapy due to high self\u2010renewal capacity, high migration rate to the site of the tumor, and with immune suppressive and anti\u2010inflammatory properties. Hence, it has a high potential of safety genetic modification of MSCs for antitumor gene expression and has paved the way for the clinical application of these cells to target the therapy of cancers and other diseases. The aim of gene therapy is targeted treatment of cancers and diseases through recovery, change, or enhancement cell performance to the sustained secretion of useful therapeutic proteins and induction expression of the functional gene in intended tissue. Recent developments in the vectors designing leading to the increase and durability of expression and improvement of the safety of the vectors that overcome a lot of problems, such as durability of expression and the host immune response. Nowadays, gene therapy approach is used by MSCs as a delivery vehicle in the preclinical and the clinical trials for the secretion of erythropoietin, recombinant antibodies, coagulation factors, cytokines, as well as angiogenic inhibitors in many blood disorders like anemia, hemophilia, and malignancies. In this study, we critically discuss the status of gene therapy by MSCs as a delivery vehicle for the treatment of blood disorders. Finally, the results of clinical trial studies are assessed, highlighting promising advantages of this emerging technology in the clinical setting.<\/jats:p>","DOI":"10.1002\/jcp.29324","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T13:08:43Z","timestamp":1573045723000},"page":"4120-4134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mesenchymal stem cells as\u00a0carrier of the therapeutic agent in the gene therapy of blood disorders"],"prefix":"10.1002","volume":"235","author":[{"given":"Navid","family":"Shomali","sequence":"first","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Immunology Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz 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