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Herein, serum miR\u2010188\u20105p was detected by real\u2010time polymerase chain reaction in patients with breast cancer, breast fibroadenoma, and healthy subjects. Circulating miR\u2010188\u20105p was abnormally elevated in patients with breast cancer as compared with these other two groups, and was reduced in patients with breast cancer following surgical treatment. Increased serum miR\u2010188\u20105p corresponded to lymph node metastasis status and TNM stages of breast cancer. A receiver operating characteristic curve analysis of the ability to circulate miR\u2010188\u20105p to distinguish between\u00a0patients with breast cancer and either noncancerous patients or patients with breast fibroadenoma yielded corresponding areas under the curve of 0.894 and 8.814. miR\u2010188\u20105p was downregulated in the highly malignant cancer line MDA\u2010MB\u2010231 relative to the less malignant MCF\u20107 cells. In vitro, functional analyses conducted via transfecting cells with mimics and inhibitors revealed miR\u2010188\u20105p to suppress breast cancer cell proliferation and migration, which was mediated by its downstream target IL6ST. Comparison of intracellular and exosomal miR\u2010188\u20105p levels indicated that miR\u2010188\u20105p was selectively sorted into exosomes derived from MDA\u2010MB\u2010231 cells rather than those from MCF\u20107 cells. However, exosomal miR\u2010188\u20105p levels in the serum of patients with breast cancer were reduced compared to healthy controls and did not differ relative to patients with breast fibroadenoma. In summary, miR\u2010188\u20105p acts in a tumor\u2010suppressive manner in breast cancer progression and may serve as a noninvasive early diagnostic biomarker and therapeutic target in breast cancer.<\/jats:p>","DOI":"10.1002\/jcp.29367","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T06:07:45Z","timestamp":1571983665000},"page":"4890-4901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["miR\u2010188\u20105p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-7286","authenticated-orcid":false,"given":"Mei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine Jiangsu University  Zhenjiang Jiangsu 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