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In this study, the phenotype and immune response of dendritic cells exposed to hyperglycemia were characterized in vitro and in vivo using the streptozotocin\u2010induced diabetes model. Dendritic cells were shown to be sensitive to hyperglycemia both during and after differentiation from bone marrow precursor cells. Dendritic cell behavior under hyperglycemic conditions was found to vary by phenotype, among which, tolerogenic dendritic cells were particularly sensitive. Expression of the costimulatory molecule CD86 was found to reliably increase when dendritic cells were exposed to hyperglycemia. Additionally, hydrogel\u2010based delivery of the anti\u2010inflammatory molecule interleukin\u201010 was shown to partially inhibit these effects in vivo.<\/jats:p>","DOI":"10.1002\/jcp.29380","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T13:25:06Z","timestamp":1572614706000},"page":"5120-5129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Brief exposure to hyperglycemia activates dendritic cells in vitro and in vivo"],"prefix":"10.1002","volume":"235","author":[{"given":"Aline M.","family":"Thomas","sequence":"first","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta Georgia"},{"name":"Parker H. 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