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Changes in proinflammatory cytokines have been shown to lead to cardiac fibrosis in patients with diabetes mellitus. This study aimed to investigate the role of miR\u2010150\u20105p in mediating cardiac inflammation and fibrosis in cardiac fibroblasts (CFs). Herein, we found that high\u2010glucose (HG) treatment significantly induced cardiac inflammation, as manifested by increased proinflammatory cytokine production (IL\u20101\u03b2) and NF\u2010\u03baB activity in CFs. Moreover, HG markedly aggravated cardiac fibrosis and increased levels of fibrotic markers (CTGF, FN, \u03b1\u2010SMA) and extracellular matrix proteins (Col\u2010I, Col\u2010III) in CFs. At the same time, HG disturbed the TGF\u2010\u03b21\/Smad signaling pathway, as evidenced by increases in TGF\u2010\u03b21 and p\u2010Smad2\/3 levels and decreases in Smad7 levels in CFs. Furthermore, we found that miR\u2010150\u20105p was upregulated by HG, which negatively regulated Smad7 expression at the posttranscription level. Further study demonstrated that cardiac inflammation and fibrosis in CFs were corrected following miR\u2010150\u20105p knockdown, but exacerbated by miR\u2010150\u20105p overexpression. These data indicated that miR\u2010150\u20105p inhibition could ameliorate NF\u2010\u03baB\u2010related inflammation and TGF\u2010\u03b21\/Smad\u2010induced cardiac fibrosis through targeting Smad7. Thus, miR\u2010150\u20105p may be a novel promising target for treating diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1002\/jcp.29386","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T05:29:50Z","timestamp":1573450190000},"page":"7769-7779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Inhibition of microRNA\u2010150\u20105p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose\u2010treated cardiac fibroblasts"],"prefix":"10.1002","volume":"235","author":[{"given":"Hui","family":"Che","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"},{"name":"Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical Sciences Harbin Heilongjiang 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