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DNA methylation is a kind of epigenetics, and a great number of previous studies have demonstrated that DNA methylation plays an important role in the process of nerve regeneration and remodeling. However, compared with the central nervous system, the peripheral nervous system shows stronger recovery after injury, which is related to the complex microenvironment and epigenetic\u00a0changes occurring at the site of injury. Therefore, what common epigenetic changes between the central and peripheral nervous systems remain to be elucidated. We first screened differential methylation genes after spinal cord injury and sciatic nerve injury using whole\u2010genome bisulfite sequencing and methylated DNA immunoprecipitation sequencing, respectively. Subsequently, a total of 16 genes had the same epigenetic changes after spinal cord injury and sciatic nerve injury. The Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed to identify the critical biological processes and pathways. Furthermore, a protein\u2212protein interaction network analysis indicated that <jats:italic>Dnm3, Ntrk3, Smurf1, Dpysl2, Kalrn, Shank1, Dlg2, Arsb, Reln, Bmp5, Numbl, Prickle2, Map6<\/jats:italic>, and <jats:italic>Htr7<\/jats:italic> were the core genes. These outcomes may provide novel insights into the molecular mechanism of the subacute phase of nerve injury. These verified genes can offer potential diagnostic and therapeutic targets for nerve injury.<\/jats:p>","DOI":"10.1002\/jcp.29393","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T09:01:56Z","timestamp":1573030916000},"page":"5171-5181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Signatures of altered DNA methylation gene expression after central and peripheral nerve injury"],"prefix":"10.1002","volume":"235","author":[{"given":"Guidong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Anatomy and Histology, School of Basic Medical Sciences Tianjin Medical University Tianjin China"},{"name":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Tianjin China"},{"name":"Department of Orthopedics Tianjin Medical University General Hospital Tianjin 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