{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:14:19Z","timestamp":1788718459413,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by neuronal degeneration and inflammation in the nerves. The role of the immune system has been concentrated by researchers in the etiopathogenesis of the disease. Given the inhibitory roles of regulatory T cells (Tregs), it is expected that increasing or activating their populations in patients with ALS can have significant therapeutic effects. Here we searched databases, including CENTRAL, MEDLINE, CINAHL Plus,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>, and ICTRP for randomized clinical trials (RCTs) and non\u2010RCTs until March 2019. For preclinical studies, we searched PubMed, Scopus, and Google Scholar up to June 2019. We also included preclinical studies, due to the lack of clinical information available, which used Tregs (or directly targeting them) for treating mice models of ALS. We identified 29 records (CENTRAL 7, MEDLINE 4, CINAHL Plus 8, and<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>10) and removed 10 duplicated publications. After screening, we identified one RCT which had been published as an abstract, three non\u2010RCTs, and four ongoing studies. We also identified 551 records (PubMed 446, Google Scholar 68, and Scopus 37) for preclinical studies and performed a meta\u2010analysis. Finally, we found three papers that matched our inclusion criteria for preclinical studies. Results indicated the effectiveness of the application of Tregs in the treatment of ALS. Our meta\u2010analysis on preclinical studies revealed that Tregs significantly prolonged survival in mice models of ALS. Overall, our analysis testified that exertion of Tregs in the treatment of ALS is a promising approach, that notwithstanding, requires further evaluations.<\/jats:p>","DOI":"10.1002\/jcp.29401","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T19:26:58Z","timestamp":1575314818000},"page":"5030-5040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Regulatory T cells for amyotrophic lateral sclerosis\/motor neuron disease: A clinical and preclinical systematic review"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-2059","authenticated-orcid":false,"given":"Misagh","family":"Rajabinejad","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"},{"name":"Department of Immunology, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-8961","authenticated-orcid":false,"given":"Sedigheh","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"},{"name":"Department of Immunology, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-0379","authenticated-orcid":false,"given":"Leila","family":"Afshar Hezarkhani","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Farabi Hospital Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-0354","authenticated-orcid":false,"given":"Farhad","family":"Salari","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-5722","authenticated-orcid":false,"given":"Ali","family":"Gorgin Karaji","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-705X","authenticated-orcid":false,"given":"Alireza","family":"Rezaiemanesh","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652411795243450"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.08.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2016.06.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2016.1193869"},{"key":"e_1_2_10_6_1","first-page":"1","article-title":"Evaluation of regulatory T lymphocytes and IL2Ra and FOXP3 gene expression in peripheral mononuclear cells from patients with amyotrophic lateral sclerosis","author":"Bargh S. 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