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In particular, we analyzed the change in renal function and oxidative stress in Sprague\u2013Dawley rats treated with OTA (0.5\u2009mg\/kg body weight, b.w.) and with RLE (90\u2009mg\/kg b.w.) by oral administration. After OTA treatment, we found alterations of biochemical and oxidative stress parameters in the kidney, related to a severe decrease of glomerular filtration rate. The RLE treatment normalized the activity of antioxidant enzymes and prevented the glomerular hyperfiltration. Histopathological examinations revealed glomerular damages and kidney cortex fibrosis in OTA\u2010rats, while we observed less severe fibrosis in OTA plus RLE group. Then, we demonstrated that oxidative stress could be the cause of OTA renal injury and that RLE reduces this effect.<\/jats:p>","DOI":"10.1002\/jcp.29425","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T07:05:35Z","timestamp":1578035135000},"page":"5386-5393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats"],"prefix":"10.1002","volume":"235","author":[{"given":"Sara","family":"Damiano","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Animal Productions University of Naples Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Iovane","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Salerno Fisciano 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