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This adipokine has been proposed as a regulator of in vitro myogenesis, but its action on in vivo regeneration is not still elucidated. We used C57BL\/6 (wild\u2010type [WT]) and adiponectin knockout (AdKO) mice injured with barium chloride at periods of 3, 7, and 14 days after injury. The AdKO presented a higher number of centralized nuclei after 7 days, and a reduction in myogenic genes was observed after 3 days. Moreover, these mice presented an increase in anti\u2010inflammatory cytokines after 3 and 7 days, and an increase in the M2 gene marker and proinflammatory cytokines after 7 days. The WT demonstrated an increase in adiponectin messenger RNA after 7 days. These results demonstrate that adiponectin is important in tissue remodeling during regeneration and that its deficiency does not compromise the maturation of muscle fibers, due to an increase in anti\u2010inflammatory response; however, there is a possible impairment in proinflammatory response and an increase in centralized myonuclei.<\/jats:p>","DOI":"10.1002\/jcp.29547","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T08:05:10Z","timestamp":1580457910000},"page":"6183-6193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Muscle regeneration in adiponectin knockout mice showed early activation of anti\u2010inflammatory response with perturbations in myogenesis"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-8217","authenticated-orcid":false,"given":"Francielle 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