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MicroRNAs are short noncoding RNA molecules that are important in several cell processes, but their role in hypoxic signalling is still poorly understood. miR\u2010210 has been linked with hypoxic mechanisms, but this relationship has been poorly characterised in prostate cancer. In this report, the link between hypoxia and miR\u2010210 in prostate cancer cells is investigated. Polymerase chain reaction\u00a0analysis demonstrates that miR\u2010210 is induced by hypoxia in prostate cancer cells using in vitro cell models and an in vivo prostate tumour xenograft model. Analysis of The Cancer Genome Atlas prostate biopsy datasets shows that miR\u2010210 is significantly correlated with Gleason grade and other clinical markers of prostate cancer progression. Neural cell adhesion molecule (NCAM) is identified as a target of miR\u2010210, providing a biological mechanism whereby hypoxia\u2010induced miR\u2010210 expression can contribute to prostate cancer. This study provides evidence that miR\u2010210 is an important regulator of cell response to hypoxic stress and proposes that its regulation of NCAM may play an important role in the pathogenesis of prostate cancer.<\/jats:p>","DOI":"10.1002\/jcp.29548","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T09:35:39Z","timestamp":1579858539000},"page":"6194-6203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["miR\u2010210 is induced by hypoxia and regulates neural cell adhesion molecule in prostate cells"],"prefix":"10.1002","volume":"235","author":[{"given":"Charlotte Zoe","family":"Angel","sequence":"first","affiliation":[{"name":"Genomic Medicine Research Group, Biomedical Sciences Research Institute Ulster University  Coleraine UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seodhna M.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Cancer Biology &amp; Therapeutics Laboratory, School of Biomolecular and Biomedical Science, Conway Institute University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Nesbitt","sequence":"additional","affiliation":[{"name":"Genomic Medicine Research Group, Biomedical Sciences Research Institute Ulster University  Coleraine UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Altnagelvin Area Hospital, Western Health &amp; Social Care Trust  Co. 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