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However, the functions of most circRNAs require further investigation. Here, we found that circBACH1 was significantly upregulated in HCC tissues and that high circBACH1 levels were closely associated with poor prognosis. In addition, circBACH1 could promote HCC growth by accelerating cell cycle progression in vitro and in vivo. We next investigated the cellular and molecular mechanisms and discovered that circBACH1 inhibited p27 translation, which influenced cell cycle progression. Moreover, we revealed that circBACH1 could combine directly with HuR using RNA immunoprecipitation assays, pull\u2010down assays, and electrophoretic mobility shift assays. The combination of these molecules facilitated HuR translocation from the nucleus to the cytoplasm according to the fluorescence in situ hybridization and immunofluorescence results. Finally, silencing HuR abrogated circBACH1's inhibition of p27 translation and abolished the circBACH1\u2010induced effect on HCC proliferation. In sum, circBACH1 plays a significant role as an oncogene through the circBACH1\/HuR\/p27 axis in HCC development.<\/jats:p>","DOI":"10.1002\/jcp.29589","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T08:22:15Z","timestamp":1580458935000},"page":"6929-6941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-602X","authenticated-orcid":false,"given":"Bingqi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of 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