{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:35:06Z","timestamp":1773214506693,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["(2018JJ2247)"],"award-info":[{"award-number":["(2018JJ2247)"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tongue squamous cell carcinoma (TSCC) is more aggressive than other head and neck tumors, and the prognosis for patients with advanced TSCC is poor. At present, comprehensive treatment based on surgery as the main method is not effective for patients with advanced TSCC. The application of PD\u20101\/PD\u2010L1 immunocheckpoint inhibitor alone in patients with TSCC has not been reported. To explore the role of PD\u20101\/PD\u2010L1, we investigated the expression of PD\u20101 and PD\u2010L1 in TSCC and analyzed the relationship between the expression of PD\u20101 and PD\u2010L1 and the related clinicopathological parameters and survival prognosis. The expression of PD\u20101 was significantly associated with palindromia (<jats:italic>p<\/jats:italic>\u2009=\u2009.015) and maximum diameter (<jats:italic>p<\/jats:italic>\u2009=\u2009.043). The expression of PD\u2010L1 in tumor cells was significantly associated with N stage (<jats:italic>P<\/jats:italic>\u2009=\u2009.024), chemotherapy (<jats:italic>p<\/jats:italic>\u2009=\u2009.032), and clinical stage (<jats:italic>p<\/jats:italic>\u2009=\u2009.019). The expression of PD\u2010L1 in infiltrating lymphocytes was significantly associated with palindromia (<jats:italic>p<\/jats:italic>\u2009=\u2009.030). Univariate and multivariate Cox analyses for prognoses of patients showed significant prognostic factors of overall survival and relapse\u2010free survival. The high expression of PD\u2010L1 on infiltrating lymphocytes for OS and RFS was an independent protective factor for patients with TSCC. The high expression of PD\u20101 on infiltrating lymphocytes and clinical stage for OS and RFS were independent risk factors for patients with TSCC. The data provide a reference for clinical treatment of TSCC with immunotherapy.<\/jats:p>","DOI":"10.1002\/jcp.29590","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T04:28:06Z","timestamp":1581049686000},"page":"6942-6953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinicopathological and prognostic significance of PD\u20101\/PD\u2010L1 axis expression in patients with tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-3161","authenticated-orcid":false,"given":"Weilun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan 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